Source:http://linkedlifedata.com/resource/pubmed/id/15187116
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2004-6-9
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pubmed:abstractText |
Alloantigen expression on host APCs is essential to initiate graft-vs-host disease (GVHD); however, critical APC subset remains to be elucidated. We compared the ability of dendritic cells (DCs) and B cells to initiate acute GVHD by an add-back study of MHC class II-expressing APCs (II(+/+)) into MHC class II-deficient (II(-/-)) mice that were resistant to CD4-dependent GVHD. Injection of host-derived, but not donor-derived, II(+/+) DCs or host-derived II(+/+) B cells, was sufficient to break GVHD resistance of II(-/-) mice and induced lethal acute GVHD. By contrast, host-derived II(+/+) B cells, both naive and LPS stimulated, failed to induce activation or tolerance of donor CD4(+) T cells. Similarly, in a model of CD8-dependent GVHD across MHC class I mismatch injection of allogeneic DCs, but not B cells, induced robust proliferation of donor CD8(+) T cells and broke GVHD resistance of chimeric recipients in which APCs were syngeneic to donors. These results demonstrate that host-derived DCs are critical in priming donor CD4(+) and CD8(+) T cells to cause GVHD, and selective targeting of host DCs may be a promising strategy to prevent GVHD.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
172
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
7393-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15187116-Acute Disease,
pubmed-meshheading:15187116-Animals,
pubmed-meshheading:15187116-Antigen-Presenting Cells,
pubmed-meshheading:15187116-B-Lymphocytes,
pubmed-meshheading:15187116-Bone Marrow Transplantation,
pubmed-meshheading:15187116-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15187116-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15187116-Dendritic Cells,
pubmed-meshheading:15187116-Graft vs Host Disease,
pubmed-meshheading:15187116-Histocompatibility Antigens Class II,
pubmed-meshheading:15187116-Lymphocyte Activation,
pubmed-meshheading:15187116-Mice,
pubmed-meshheading:15187116-Mice, Knockout,
pubmed-meshheading:15187116-Transplantation, Homologous
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pubmed:year |
2004
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pubmed:articleTitle |
Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease.
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pubmed:affiliation |
Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, MI 48109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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