rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2004-8-13
|
pubmed:abstractText |
The INK4a-ARF [CDKN2A]- locus on chromosome 9p21 encodes for two tumour suppressor proteins, p16INK4a and p14ARF, which act as upstream regulators of the Rb-CDK4 and p53 pathways. To study the contribution of each pathway to the carcinogenesis of Barrett's adenocarcinoma, we analysed the alterations of p14ARF and p16INK4a in preneoplastic and neoplastic lesions of this disease.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0945-6317
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
445
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
135-41
|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15185075-Barrett Esophagus,
pubmed-meshheading:15185075-Carcinoma in Situ,
pubmed-meshheading:15185075-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:15185075-DNA, Neoplasm,
pubmed-meshheading:15185075-DNA Methylation,
pubmed-meshheading:15185075-Disease Progression,
pubmed-meshheading:15185075-Esophageal Neoplasms,
pubmed-meshheading:15185075-Gene Silencing,
pubmed-meshheading:15185075-Humans,
pubmed-meshheading:15185075-Immunohistochemistry,
pubmed-meshheading:15185075-Loss of Heterozygosity,
pubmed-meshheading:15185075-Microdissection,
pubmed-meshheading:15185075-Polymerase Chain Reaction,
pubmed-meshheading:15185075-Prognosis,
pubmed-meshheading:15185075-Promoter Regions, Genetic,
pubmed-meshheading:15185075-Tumor Suppressor Protein p14ARF
|
pubmed:year |
2004
|
pubmed:articleTitle |
INK4a-ARF alterations in Barrett's epithelium, intraepithelial neoplasia and Barrett's adenocarcinoma.
|
pubmed:affiliation |
Institute of Pathology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany. Michael.Vieth@medizin.uni-magdeburg.de
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pubmed:publicationType |
Journal Article,
Comparative Study
|