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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2004-9-14
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pubmed:abstractText |
Id (inhibitor of differentiation) proteins play important roles in cell differentiation, cell cycle control, and apoptosis. They act as negative regulators of basic helix-loop-helix-type transcription factors, which positively regulate differentiation of various cell types. Id proteins work to block B lymphocyte (B cell) maturation at an early differentiation step, as demonstrated by gain-of-function studies. In recent years a series of gene-targeted mice lacking different Ids have been generated. Analyses of these gene-targeted mice provide information useful for understanding the physiological roles of Ids in B cell biology. Id3 is required for proper B cell functions and acts by controlling the cell cycle. Upon B cell activation, Id2 acts as a negative regulator to prevent potentially harmful effects brought about by excessive immunological reactions; one of its special roles is to maintain low serum concentrations of immunoglobulin E (IgE). The Id2 protein does this by antagonizing E2A and Pax5 activities, both of which are required for proper B cell activation. This review presents several new insights into B cell differentiation and activation programs and the physiological role of Id proteins in B cell activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AICDA (activation-induced cytidine...,
http://linkedlifedata.com/resource/pubmed/chemical/B-Cell-Specific Activator Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Cytidine Deaminase,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ID3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Idb2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pax5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tcf3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0946-2716
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
592-9
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pubmed:dateRevised |
2011-7-8
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pubmed:meshHeading |
pubmed-meshheading:15184986-Animals,
pubmed-meshheading:15184986-B-Cell-Specific Activator Protein,
pubmed-meshheading:15184986-B-Lymphocytes,
pubmed-meshheading:15184986-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:15184986-Cell Cycle,
pubmed-meshheading:15184986-Cytidine Deaminase,
pubmed-meshheading:15184986-DNA-Binding Proteins,
pubmed-meshheading:15184986-Immunoglobulin Class Switching,
pubmed-meshheading:15184986-Immunoglobulin E,
pubmed-meshheading:15184986-Inhibitor of Differentiation Protein 2,
pubmed-meshheading:15184986-Inhibitor of Differentiation Proteins,
pubmed-meshheading:15184986-Lymphocyte Activation,
pubmed-meshheading:15184986-Mice,
pubmed-meshheading:15184986-Mice, Knockout,
pubmed-meshheading:15184986-Neoplasm Proteins,
pubmed-meshheading:15184986-Repressor Proteins,
pubmed-meshheading:15184986-Transcription Factors,
pubmed-meshheading:15184986-Transforming Growth Factor beta
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pubmed:year |
2004
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pubmed:articleTitle |
Role of Id proteins in B lymphocyte activation: new insights from knockout mouse studies.
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pubmed:affiliation |
Center for Molecular Biology and Genetics, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, 606-8507 Kyoto, Japan. msugai@virus.kyoto-u.ac.jp
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pubmed:publicationType |
Journal Article,
Review
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