Source:http://linkedlifedata.com/resource/pubmed/id/15184253
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2004-6-8
|
| pubmed:abstractText |
Alkylating N-nitroso compounds can interact directly with DNA, forming O(6)-alkylguanine, a DNA adduct proved to be mutagenic and carcinogenic if not sufficiently repaired. A specific DNA repair enzyme, O(6)-methylguanine-DNA methyltransferase (MGMT), can remove the alkyl group from the O(6)-position of the guanine, thereby preventing its mutagenic and carcinogenic effects. Inactivation of the MGMT gene in association with promoter hypermethylation results in persistence of O(6)-alkylguanine in DNA, leading to G:C to A:T transition mutation and these G:C to A:T transition mutations can inactivate p53 tumor suppressor gene or activate ras proto-oncogene.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1055-9965
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
967-75
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:15184253-Adult,
pubmed-meshheading:15184253-Aged,
pubmed-meshheading:15184253-Aged, 80 and over,
pubmed-meshheading:15184253-Carcinoma, Squamous Cell,
pubmed-meshheading:15184253-DNA Adducts,
pubmed-meshheading:15184253-DNA Methylation,
pubmed-meshheading:15184253-DNA Repair Enzymes,
pubmed-meshheading:15184253-Gene Silencing,
pubmed-meshheading:15184253-Guanine,
pubmed-meshheading:15184253-Head and Neck Neoplasms,
pubmed-meshheading:15184253-Humans,
pubmed-meshheading:15184253-Male,
pubmed-meshheading:15184253-Middle Aged,
pubmed-meshheading:15184253-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:15184253-Polymerase Chain Reaction,
pubmed-meshheading:15184253-Prognosis,
pubmed-meshheading:15184253-Promoter Regions, Genetic,
pubmed-meshheading:15184253-Risk Factors,
pubmed-meshheading:15184253-Survival Analysis
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma.
|
| pubmed:affiliation |
Department of Pathology, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans' Hospital, Little Rock, AR 72205, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|