Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-6-8
pubmed:abstractText
The most common source of Salmonella infections in humans is food of poultry origin. Salmonella enterica serovar Enteritidis has a particular affinity for the contamination of the egg supply. In this study, the medium-chain fatty acids (MCFA), caproic, caprylic, and capric acid, were evaluated for the control of Salmonella serovar Enteritidis in chickens. All MCFA were growth inhibiting at low concentrations in vitro, with caproic acid being the most potent. Contact of Salmonella serovar Enteritidis with low concentrations of MCFA decreased invasion in the intestinal epithelial cell line T84. By using transcriptional fusions between the promoter of the regulatory gene of the Salmonella pathogenicity island I, hilA, and luxCDABE genes, it was shown that all MCFA decreased the expression of hilA, a key regulator related to the invasive capacity of Salmonella. The addition of caproic acid (3 g/kg of feed) to the feed of chicks led to a significant decrease in the level of colonization of ceca and internal organs by Salmonella serovar Enteritidis at 3 days after infection of 5-day-old chicks. These results suggest that MCFA have a synergistic ability to suppress the expression of the genes required for invasion and to reduce the numbers of bacteria in vivo. Thus, MCFA are potentially useful products for reducing the level of colonization of chicks and could ultimately aid in the reduction of the number of contaminated eggs in the food supply.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-10438766, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-10487745, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-10565427, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-11181152, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-11408658, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-11553232, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-11755416, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-11888650, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-12076524, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-12453229, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-12878382, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-2160435, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-3201669, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-4670656, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-8686137, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-8951817, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-9088614, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-9228686, http://linkedlifedata.com/resource/pubmed/commentcorrection/15184160-9469754
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0099-2240
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3582-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Medium-chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enterica serovar Enteritidis.
pubmed:affiliation
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, B-9820 Merelbeke, Belgium. filip.vanimmerseel@UGent.be
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't