15183052

Source:http://linkedlifedata.com/resource/pubmed/id/15183052

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0011311, umls-concept:C0179226, umls-concept:C0206155, umls-concept:C0282688, umls-concept:C2936603
pubmed:issue	1
pubmed:dateCreated	2004-6-8
pubmed:abstractText	We sequenced the envelope (E) genes of 59 DEN-2 isolates collected from ten Caribbean islands, six South American countries, and two Central American countries between 1981 and 2000, a period characterized by hyperendemicity and increased incidence of severe dengue. Fifty-two isolates belonged to "American/Asian" subtype IIIb, possessing a characteristic polar residue at envelope aa position 390 (N [n = 48] or S [n = 4]) common to that group. Six isolates from Trinidad (1981), Honduras (1991 [4]), and El Salvador (1987) fell into the "Native American" subtype V (D at aa 390), and one from Honduras (1986) belonged to "Asian" subtype I. The data suggest that after its first isolation in the Caribbean in 1981, genotype IIIb spread throughout the Americas and effectively replaced subtype V throughout the Caribbean basin. The strain also evolved into several distinct lineages, based on substitutions in the E glycoprotein (amino acids 91 and 131), two of which were still in circulation in 2000. Interestingly, a molecular clock did not fit the data well, suggesting that other sources of rate variation, such as differential selection or differences in effective population sizes, may exist among lineages. Our results indicate the importance of large temporal- and geographical-scale phylogenetic studies in understanding disease dynamics, particularly where replacements between regions can occur.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0110674
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0042-6822
pubmed:author	pubmed-author:BennettShannon NSN, pubmed-author:CarringtonChristine V FCV, pubmed-author:FosterJerome EJE, pubmed-author:McMillanW OwenWO, pubmed-author:VaughanHelenH
pubmed:issnType	Print
pubmed:day	20
pubmed:volume	324
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	48-59
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15183052-Caribbean Region, pubmed-meshheading:15183052-Dengue Virus, pubmed-meshheading:15183052-Evolution, Molecular, pubmed-meshheading:15183052-Phylogeny, pubmed-meshheading:15183052-Time Factors
pubmed:year	2004
pubmed:articleTitle	Phylogeography and molecular evolution of dengue 2 in the Caribbean basin, 1981-2000.
pubmed:affiliation	Department of Preclinical Sciences, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't