Linked Life Data

15181569

Source:http://linkedlifedata.com/resource/pubmed/id/15181569

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2004-6-7
pubmed:abstractText
We assessed the prevalence and natural history of malarial parasitemia by use of microscopy and polymerase chain reaction (PCR) in 314 asymptomatic children in Kampala, Uganda. The prevalence of asymptomatic parasitemia was 17% by microscopy and 47% by PCR. Children with parasitemia identified by microscopy had a 5-fold higher rate of subsequent symptomatic malaria, compared with children without detectable parasitemia. Children with parasitemia identified by PCR alone had a similar rate of subsequent symptomatic malaria, compared with children without detectable parasitemia. Among microscopy-positive children who later developed symptomatic malaria, 47% had strains identical to those identified at enrollment, and the proportion of symptomatic episodes due to persistent strains remained high for 3 months. Among the PCR-positive/microscopy-negative children, only 17% had identical genotyping patterns at the onset of symptomatic malaria, with most of these episodes occurring during the first month. Asymptomatic parasitemia detected by microscopy, but not by PCR, strongly predicted subsequent clinical malaria, often due to persistent infection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
189
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2220-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children.
pubmed:affiliation
Makerere University Medical School, Kampala, Uganda.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't