Linked Life Data

15181268

Source:http://linkedlifedata.com/resource/pubmed/id/15181268

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2004-6-7
pubmed:abstractText
Identification of the mechanisms by which a T cell is able to sense ligands of varying strength, such as those that mediate tumor growth, viral evasion, and autoimmunity, is a major goal of T-cell activation studies. In recent years, parameters important for T-cell activation by strong ligands (agonists) are beginning to be characterized. Here, we review our current work on the factors that are critical for T-cell activation by ligands that differ in potency, typified by full agonists, weak agonists, partial agonists, and antagonists. Furthermore, we discuss mechanisms contributing to the lack of a full range of effector functions observed in T cells following their stimulation by suboptimal ligands. Finally, we present strategies for the design of peptide-based therapies to control activation of polyclonal, autoreactive T-cell populations.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0257-277X
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-40
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Defining the parameters necessary for T-cell recognition of ligands that vary in potency.
pubmed:affiliation
Department of Microbiology and Immunology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't