|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2004-6-7
|
|
pubmed:abstractText |
Conventional nuclear medicine imaging with large radiolabeled molecules such as antitumor antibodies suffers from slow localization and clearance. Pretargeting is under active investigation as an alternative using either (strept)avidin/biotin, bispecific antibodies, or oligomers. However, only the use of oligomers such as phosphorodiamidate morpholinos (MORFs) in pretargeting offers the potential of signal amplification at the target. Amplification targeting is a multistep procedure with the potential to greatly improve target localization of radioactivity (and eventually drugs) through the intermediate use of polymers conjugated with multiple copies of oligomers.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0161-5505
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
45
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1087-95
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:15181145-Animals,
pubmed-meshheading:15181145-Cell Line, Tumor,
pubmed-meshheading:15181145-Colonic Neoplasms,
pubmed-meshheading:15181145-Drug Delivery Systems,
pubmed-meshheading:15181145-Feasibility Studies,
pubmed-meshheading:15181145-Gene Targeting,
pubmed-meshheading:15181145-Humans,
pubmed-meshheading:15181145-Indium Radioisotopes,
pubmed-meshheading:15181145-Isotope Labeling,
pubmed-meshheading:15181145-Metabolic Clearance Rate,
pubmed-meshheading:15181145-Mice,
pubmed-meshheading:15181145-Mice, Nude,
pubmed-meshheading:15181145-Nucleic Acid Amplification Techniques,
pubmed-meshheading:15181145-Oligonucleotides,
pubmed-meshheading:15181145-Organ Specificity,
pubmed-meshheading:15181145-Radiopharmaceuticals,
pubmed-meshheading:15181145-Technetium,
pubmed-meshheading:15181145-Tissue Distribution,
pubmed-meshheading:15181145-Tumor Markers, Biological
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Amplification targeting: a modified pretargeting approach with potential for signal amplification-proof of a concept.
|
|
pubmed:affiliation |
Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Evaluation Studies,
Validation Studies
|
