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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2004-6-7
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pubmed:abstractText |
FcgammaRIIB are low-affinity immunoglobulin (Ig)G receptors that we previously demonstrated to negatively regulate IgE-induced mast cell activation when coaggregated with FcepsilonRI. Here, we engineered and characterized a bispecific reagent capable of coaggregating FcgammaRIIB with FcepsilonRI on human mast cells and basophils.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bispecific,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/FCGR2A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FCGR2B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0105-4538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
772-80
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15180766-Antibodies, Bispecific,
pubmed-meshheading:15180766-Antigens,
pubmed-meshheading:15180766-Basophils,
pubmed-meshheading:15180766-Cells, Cultured,
pubmed-meshheading:15180766-Chromatography, High Pressure Liquid,
pubmed-meshheading:15180766-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15180766-Fluorescent Antibody Technique,
pubmed-meshheading:15180766-Histamine Antagonists,
pubmed-meshheading:15180766-Histamine Release,
pubmed-meshheading:15180766-Humans,
pubmed-meshheading:15180766-Immunoglobulin E,
pubmed-meshheading:15180766-Mast Cells,
pubmed-meshheading:15180766-Receptor Aggregation,
pubmed-meshheading:15180766-Receptors, IgE,
pubmed-meshheading:15180766-Receptors, IgG
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pubmed:year |
2004
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pubmed:articleTitle |
A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils.
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pubmed:affiliation |
Tanox Inc., Houston, TX, USA.
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pubmed:publicationType |
Journal Article
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