Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2004-6-7
pubmed:abstractText
An increased traffic of circulating CD34+ Hemopoietic Precursors Cells (HPC) is an important feature of systemic allergic inflammation. Bacteria and bacterial products are capable of stimulating the transcription of the maturational cytokines IL12 and IFNs through the activation of Toll-Like-Receptor and the subsequent nuclear translocation of the NF-kappaB factor. In this study the probiotics differentiation/maturational effect potential on CD34+ HPC has been investigated. Fourteen consecutive subjects, 9M and 5F, aged 6-48, with clinical symptoms of asthma and /or conjunctivitis, rhinitis, urticaria, atopic dermatitis, food allergy and irritable bowel syndrome were enrolled. Allergen-specific serum IgE were found in twelve patients. Flow-cytometric measurement of peripheral blood CD34dim/bright HPC values were assessed before and after 30 days of therapy, consisting in the oral administration of one sachet a day of ENDOLAC (UCB Pharma, Turin, Italy). Each sachet contained a mixture of Lactobacillus acidophilus, L. delbrueckii and Streptococcus thermophilus for a total of 1 x 10(9) live bacteria. Circulating CD34+ cell values significantly (p < 0.001) reduced after the treatment. ENDOLAC, thus, may improve the efficacy of the standard treatments of allergic diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1764-1489
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-22
pubmed:dateRevised
2008-2-26
pubmed:meshHeading
pubmed-meshheading:15180351-Adolescent, pubmed-meshheading:15180351-Adult, pubmed-meshheading:15180351-Antibody Specificity, pubmed-meshheading:15180351-Antigens, CD34, pubmed-meshheading:15180351-Cell Differentiation, pubmed-meshheading:15180351-Child, pubmed-meshheading:15180351-Cytokines, pubmed-meshheading:15180351-Female, pubmed-meshheading:15180351-Hematopoietic Stem Cells, pubmed-meshheading:15180351-Humans, pubmed-meshheading:15180351-Hypersensitivity, Immediate, pubmed-meshheading:15180351-Immunoglobulin E, pubmed-meshheading:15180351-Irritable Bowel Syndrome, pubmed-meshheading:15180351-Lactobacillus, pubmed-meshheading:15180351-Lactobacillus acidophilus, pubmed-meshheading:15180351-Male, pubmed-meshheading:15180351-Middle Aged, pubmed-meshheading:15180351-Probiotics, pubmed-meshheading:15180351-Streptococcus
pubmed:year
2004
pubmed:articleTitle
Probiotics reduce the CD34+ hemopoietic precursor cell increased traffic in allergic subjects.
pubmed:affiliation
Allergy and Clinical Immunology O.U., SS Annunziata Hospital, AUSL TA1, Taranto, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies