|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-6-4
|
|
pubmed:abstractText |
Second mitochondria-derived activator of caspase (Smac) has been implicated in the activation of apoptosis in response to cell stress. We screened for Smac/DIABLO-binding protein for further understanding of Smac-mediated apoptosis. We identified NADE, previously known as p75NTR-associated cell death executor, as a Smac-binding protein. Smac-NADE interaction was mapped to the N-terminal region of Samc and the C-terminal region of NADE. Co-expression of NADE and Smac promotes TRAIL-induced apoptosis in MCF-7 cells. Interestingly, the co-presence of Smac and NADE inhibits XIAP-mediated Smac ubiquitination. In conclusion, our results provide the first evidence that the interaction between Smac and NADE regulates apoptosis through the inhibition of Smac ubiquitination.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DIABLO protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NGFRAP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/X-Linked Inhibitor of Apoptosis...,
http://linkedlifedata.com/resource/pubmed/chemical/XIAP protein, human
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
25
|
|
pubmed:volume |
319
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
649-54
|
|
pubmed:dateRevised |
2008-5-14
|
|
pubmed:meshHeading |
pubmed-meshheading:15178455-Apoptosis,
pubmed-meshheading:15178455-Apoptosis Regulatory Proteins,
pubmed-meshheading:15178455-Carrier Proteins,
pubmed-meshheading:15178455-Cell Line,
pubmed-meshheading:15178455-Humans,
pubmed-meshheading:15178455-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15178455-Membrane Glycoproteins,
pubmed-meshheading:15178455-Mitochondrial Proteins,
pubmed-meshheading:15178455-Protein Binding,
pubmed-meshheading:15178455-Proteins,
pubmed-meshheading:15178455-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:15178455-Tumor Necrosis Factor-alpha,
pubmed-meshheading:15178455-Two-Hybrid System Techniques,
pubmed-meshheading:15178455-X-Linked Inhibitor of Apoptosis Protein
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis.
|
|
pubmed:affiliation |
Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, Seoul 120-750, Republic of Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
