| pubmed-article:1517754 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1517754 | lifeskim:mentions | umls-concept:C1550320 | lld:lifeskim |
| pubmed-article:1517754 | lifeskim:mentions | umls-concept:C0005562 | lld:lifeskim |
| pubmed-article:1517754 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:1517754 | lifeskim:mentions | umls-concept:C0752105 | lld:lifeskim |
| pubmed-article:1517754 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:1517754 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:1517754 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1517754 | pubmed:dateCreated | 1992-10-8 | lld:pubmed |
| pubmed-article:1517754 | pubmed:abstractText | Total biopterin (T-BP) levels in the ventricular cerebrospinal fluid (CSF) and clinical features of 19 patients with juvenile parkinsonism (JP: Parkinson's disease manifesting below the age of 40) were evaluated and compared with 61 patients with classical Parkinson's disease (classical PD: symptoms developing at the age of 40 or above). The JP patients were divided into two subgroups: JP-I; those with good response to levodopa followed by marked motor fluctuations and dopa-induced dyskinesias (DID), JP-II; those with milder response than JP-I with less fluctuations and DID being more similar to classical PD. Both of the mean ventricular CSF T-BP concentrations in the JP and classical PD patients were significantly lower than that in neurological controls. Moreover, the mean T-BP level in the JP-I was markedly lower than that in the JP-II or classical PD. Total biopterin levels revealed a gaussian distribution in the classical PD. However, a bimodal distribution was noted in the JP, with the lower peak consisting of only JP-I patients. These results seem to indicate that JP-II represents early-onset classical PD, while JP-I represents a distinct subgroup having a different physiopathology from classical PD. | lld:pubmed |
| pubmed-article:1517754 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1517754 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517754 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1517754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517754 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1517754 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1517754 | pubmed:issn | 0022-510X | lld:pubmed |
| pubmed-article:1517754 | pubmed:author | pubmed-author:KondoTT | lld:pubmed |
| pubmed-article:1517754 | pubmed:author | pubmed-author:FurukawaYY | lld:pubmed |
| pubmed-article:1517754 | pubmed:author | pubmed-author:NarabayashiHH | lld:pubmed |
| pubmed-article:1517754 | pubmed:author | pubmed-author:MizunoYY | lld:pubmed |
| pubmed-article:1517754 | pubmed:author | pubmed-author:NishiKK | lld:pubmed |
| pubmed-article:1517754 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1517754 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:1517754 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1517754 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1517754 | pubmed:pagination | 207-13 | lld:pubmed |
| pubmed-article:1517754 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1517754 | pubmed:meshHeading | pubmed-meshheading:1517754-... | lld:pubmed |
| pubmed-article:1517754 | pubmed:meshHeading | pubmed-meshheading:1517754-... | lld:pubmed |
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| pubmed-article:1517754 | pubmed:meshHeading | pubmed-meshheading:1517754-... | lld:pubmed |
| pubmed-article:1517754 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1517754 | pubmed:articleTitle | Juvenile parkinsonism: ventricular CSF biopterin levels and clinical features. | lld:pubmed |
| pubmed-article:1517754 | pubmed:affiliation | Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:1517754 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1517754 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1517754 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
