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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1992-10-8
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pubmed:abstractText |
Total biopterin (T-BP) levels in the ventricular cerebrospinal fluid (CSF) and clinical features of 19 patients with juvenile parkinsonism (JP: Parkinson's disease manifesting below the age of 40) were evaluated and compared with 61 patients with classical Parkinson's disease (classical PD: symptoms developing at the age of 40 or above). The JP patients were divided into two subgroups: JP-I; those with good response to levodopa followed by marked motor fluctuations and dopa-induced dyskinesias (DID), JP-II; those with milder response than JP-I with less fluctuations and DID being more similar to classical PD. Both of the mean ventricular CSF T-BP concentrations in the JP and classical PD patients were significantly lower than that in neurological controls. Moreover, the mean T-BP level in the JP-I was markedly lower than that in the JP-II or classical PD. Total biopterin levels revealed a gaussian distribution in the classical PD. However, a bimodal distribution was noted in the JP, with the lower peak consisting of only JP-I patients. These results seem to indicate that JP-II represents early-onset classical PD, while JP-I represents a distinct subgroup having a different physiopathology from classical PD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benserazide,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Biopterin,
http://linkedlifedata.com/resource/pubmed/chemical/Carbidopa,
http://linkedlifedata.com/resource/pubmed/chemical/Levodopa
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-510X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1517754-Adult,
pubmed-meshheading:1517754-Age Factors,
pubmed-meshheading:1517754-Benserazide,
pubmed-meshheading:1517754-Biological Markers,
pubmed-meshheading:1517754-Biopterin,
pubmed-meshheading:1517754-Carbidopa,
pubmed-meshheading:1517754-Female,
pubmed-meshheading:1517754-Humans,
pubmed-meshheading:1517754-Levodopa,
pubmed-meshheading:1517754-Male,
pubmed-meshheading:1517754-Middle Aged,
pubmed-meshheading:1517754-Motor Neurons,
pubmed-meshheading:1517754-Parkinson Disease
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pubmed:year |
1992
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pubmed:articleTitle |
Juvenile parkinsonism: ventricular CSF biopterin levels and clinical features.
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pubmed:affiliation |
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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