Source:http://linkedlifedata.com/resource/pubmed/id/15177308
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2004-6-4
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pubmed:abstractText |
There is increasing evidence to suggest that toxic oxygen radicals play a role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to investigate the effects of naringin (Ng), a bioflavonoid in I/R induced renal failure in rats. The protective effect of naringin against the damage inflicted by reactive oxygen species (ROS) during renal I/R was investigated in Sprague-Dawley rats using histopathological and biochemical parameters. In one set of experiments animals were unilaterally nephrectomized, and subjected to 45 min of left renal pedicle occlusion and in another set both the renal pedicles were occluded for 45 min followed by 24h of reperfusion. Naringin (400 mg kg(-1), p.o.) was administered 60 min prior to ischemia. At the end of the reperfusion period, rats were sacrificed. Thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) levels, catalase (CAT), and superoxide dismutase (SOD) activities were determined in renal tissue. Serum creatinine and blood urea nitrogen (BUN) concentrations were measured for the evaluation of renal function. Ischemic control animals demonstrated severe deterioration of renal function, renal morphology and a significant renal oxidative stress. Pretreatment of animals with naringin markedly attenuated renal dysfunction, morphological alterations, reduced elevated TBARS levels and restored the depleted renal antioxidant enzymes. The findings imply that ROS play a causal role in I/R induced renal injury and naringin exert renoprotective effects probably by the radical scavenging and antioxidant activities.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Flavanones,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Thiobarbituric Acid Reactive...,
http://linkedlifedata.com/resource/pubmed/chemical/naringin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1043-6618
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2004 Elsevier Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15177308-Administration, Oral,
pubmed-meshheading:15177308-Animals,
pubmed-meshheading:15177308-Blood Urea Nitrogen,
pubmed-meshheading:15177308-Catalase,
pubmed-meshheading:15177308-Creatinine,
pubmed-meshheading:15177308-Disease Models, Animal,
pubmed-meshheading:15177308-Flavanones,
pubmed-meshheading:15177308-Flavonoids,
pubmed-meshheading:15177308-Free Radicals,
pubmed-meshheading:15177308-Glutathione,
pubmed-meshheading:15177308-Kidney,
pubmed-meshheading:15177308-Kidney Diseases,
pubmed-meshheading:15177308-Lipid Peroxidation,
pubmed-meshheading:15177308-Male,
pubmed-meshheading:15177308-Nephrectomy,
pubmed-meshheading:15177308-Oxidative Stress,
pubmed-meshheading:15177308-Rats,
pubmed-meshheading:15177308-Rats, Sprague-Dawley,
pubmed-meshheading:15177308-Reperfusion Injury,
pubmed-meshheading:15177308-Superoxide Dismutase,
pubmed-meshheading:15177308-Thiobarbituric Acid Reactive Substances
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pubmed:year |
2004
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pubmed:articleTitle |
The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats.
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pubmed:affiliation |
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India. dr_chopra_k@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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