Source:http://linkedlifedata.com/resource/pubmed/id/15177127
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2004-6-15
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| pubmed:abstractText |
Elevated serum low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) and decreased high density lipoprotein cholesterol (HDL-C) levels are established risk factors for cardiovascular disease (CVD). To identify quantitative trait loci influencing lipid levels, we conducted genome-wide linkage analyses of total serum cholesterol (TSC), HDL-C, ln-transformed TG (LNTG) and LDL-C levels in 612 individuals from 28 families of the Amish Family Diabetes Study (AFDS). Subjects were genotyped for 373 microsatellite markers covering all 22 autosomes and the X chromosome at an average density of 9.7 centimorgans. All lipid traits exhibited moderate estimated heritability (h2 +/- S.E.): TSC, 0.63 +/- 0.11; HDL-C, 0.54 +/- 0.08; LNTG, 0.37 +/- 0.08; LDL-C, 0.62 +/- 0.10. The highest logarithm of the odds (LOD) score observed was 2.47 (P = 0.0003), at 3p25 for LDL-C. LOD scores exceeding 2.0 (P < 0.001) were also observed at 2p23 (LOD = 2.17) and 19p13 (LOD = 2.23) for LDL-C, and at 11q23 (LOD = 2.03) for LNTG. Three additional regions exhibited LOD scores greater than 1.5, corresponding to a P-value of <0.005. Many of the regions suggestively linked in this genome-wide scan contain genes encoding proteins with established roles in lipid metabolism, including apolipoproteins, peroxisome proliferater-activated receptor-gamma and the LDL receptor.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0021-9150
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
173
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
89-96
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:15177127-Adult,
pubmed-meshheading:15177127-Age Factors,
pubmed-meshheading:15177127-Aged,
pubmed-meshheading:15177127-Cholesterol, HDL,
pubmed-meshheading:15177127-Cholesterol, LDL,
pubmed-meshheading:15177127-Cohort Studies,
pubmed-meshheading:15177127-Coronary Artery Disease,
pubmed-meshheading:15177127-European Continental Ancestry Group,
pubmed-meshheading:15177127-Female,
pubmed-meshheading:15177127-Genetic Linkage,
pubmed-meshheading:15177127-Genetic Testing,
pubmed-meshheading:15177127-Genetics, Population,
pubmed-meshheading:15177127-Genome, Human,
pubmed-meshheading:15177127-Genotype,
pubmed-meshheading:15177127-Humans,
pubmed-meshheading:15177127-Hypercholesterolemia,
pubmed-meshheading:15177127-Lod Score,
pubmed-meshheading:15177127-Male,
pubmed-meshheading:15177127-Middle Aged,
pubmed-meshheading:15177127-Probability,
pubmed-meshheading:15177127-Risk Factors,
pubmed-meshheading:15177127-Sex Factors
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| pubmed:year |
2004
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| pubmed:articleTitle |
A genome-wide scan of serum lipid levels in the Old Order Amish.
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| pubmed:affiliation |
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|