Linked Life Data

15177049

Source:http://linkedlifedata.com/resource/pubmed/id/15177049

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-6-4
pubmed:abstractText
Preferential repair of the transcribed strand of active genes is usually attributed to a coupling protein that dislodges RNA polymerase stalled at a damage site and recruits repair enzymes. Experimental observations of the effect of transcription on preferential repair in Escherichia coli are contradictory and inexplicable by this model. In this study, it is argued that the multiple conformations displayed by a stalled RNA polymerase result in two sub-pathways for repair: Mfd coupled and direct. Together with the fact that RNA polymerase recruits the repair enzymes in a promoter dependent manner, an integrated mechanistic model is proposed that is capable of explaining the effect of transcription on preferential repair reported in literature. The quantitative behavior of the model is illustrated by describing the various reactions using a biochemical network. The implications of the model on the mechanism for transcription-coupled repair in higher organisms are briefly discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1568-7864
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Elsevier B.V.
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
343-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
An integrated mechanistic model for transcription-coupled nucleotide excision repair.
pubmed:affiliation
Department of Chemical Engineering, University of Delaware, Newark, DE 19716, USA. spate6@mednet.swmed.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.