Linked Life Data

15175835

Source:http://linkedlifedata.com/resource/pubmed/id/15175835

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2004-8-31
pubmed:abstractText
Solitary pulmonary nodule (SPN, intraparenchymal lung mass <3 cm) is often a diagnostic challenge. This study was performed to evaluate the diagnostic accuracy of( 18)F-fluorodeoxyglucose positron emission tomography (FDG PET) in radiologically indeterminate SPN < or =10 mm on spiral CT. Between August 1997 and March 2001, we identified all patients with radiologically indeterminate SPNs < or =10 mm who were referred for FDG PET imaging at the VU University Medical Centre. All PET scans were retrospectively reviewed by an experienced nuclear medicine physician. PET was considered positive in cases with at least moderately enhanced focal uptake, and otherwise as negative. Lesions were considered benign on the basis of histology, no growth during 1.5 years or disappearance within at least 6 months. Thirty-five patients with 36 SPNs < or =10 mm in diameter at clinical presentation were identified (one patient had two metachronous lesions). In 13 of 14 malignant nodules and in two of 22 benign nodules, diagnosis was confirmed by histology. Prevalence of malignancy was 39%. PET imaging correctly identified 30 of 36 small lesions. One lesion proved to be false negative on PET (CT: 10 mm), and in five lesions, PET scans proved to be false positive. Specificity was 77% (17/22; 95% CI: 0.55-0.92), sensitivity 93% (13/14; 95% CI: 0.66-1.0), positive predictive value 72% (13/18; 95% CI: 0.46-0.90) and negative predictive value 94% (17/18; 95% CI: 0.73-1.0). This retrospective study suggests that FDG PET imaging could be a useful tool in differentiating benign from malignant SPNs < or =10 mm in diameter at clinical presentation. Such results may help in the design of larger prospective trials with structured clinical work-up.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1619-7070
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1231-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
The performance of( 18)F-fluorodeoxyglucose positron emission tomography in small solitary pulmonary nodules.
pubmed:affiliation
Department of Pulmonary Diseases, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Comparative Study, Evaluation Studies, Validation Studies