| pubmed-article:1517567 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1517567 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1517567 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:1517567 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:1517567 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:1517567 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:1517567 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1517567 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:1517567 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1517567 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1517567 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1517567 | pubmed:dateCreated | 1992-10-7 | lld:pubmed |
| pubmed-article:1517567 | pubmed:abstractText | Blood monocytes are important cellular sources of a vast array of bioactive substances, including regulatory and chemotactic cytokines. The regulation of these cytokines is of critical importance to the expression of acute and chronic inflammatory responses. IL-7, a T and B cell-activating cytokine, has recently been shown to have stimulatory effects on the expression of several monocyte-derived proinflammatory cytokines. We now describe the induction of IL-8 mRNA and extracellular protein from human blood monocytes by IL-7. The up-regulation of IL-8 mRNA by IL-7 was not altered by concomitant treatment with cycloheximide, suggesting that the direct stimulatory effects of IL-7 were not dependent upon de novo protein synthesis. In addition, IL-7 significantly potentiated the production of IL-8 from LPS-, TNF-, and IL-1-treated peripheral blood monocytes. Our findings suggest that IL-7 may play a critical role in the modulation of macrophage-derived cytokine expression and may function in vivo as an important proinflammatory cytokine. | lld:pubmed |
| pubmed-article:1517567 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517567 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517567 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517567 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1517567 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1517567 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1517567 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1517567 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1517567 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1517567 | pubmed:author | pubmed-author:KunkelS LSL | lld:pubmed |
| pubmed-article:1517567 | pubmed:author | pubmed-author:AllenR MRM | lld:pubmed |
| pubmed-article:1517567 | pubmed:author | pubmed-author:StrieterR MRM | lld:pubmed |
| pubmed-article:1517567 | pubmed:author | pubmed-author:BurdickM DMD | lld:pubmed |
| pubmed-article:1517567 | pubmed:author | pubmed-author:StandifordT... | lld:pubmed |
| pubmed-article:1517567 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1517567 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1517567 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:1517567 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1517567 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1517567 | pubmed:pagination | 2035-9 | lld:pubmed |
| pubmed-article:1517567 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1517567 | pubmed:meshHeading | pubmed-meshheading:1517567-... | lld:pubmed |
| pubmed-article:1517567 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1517567 | pubmed:articleTitle | IL-7 up-regulates the expression of IL-8 from resting and stimulated human blood monocytes. | lld:pubmed |
| pubmed-article:1517567 | pubmed:affiliation | Department of Medicine, University of Michigan Medical School, Ann Arbor 48109-0602. | lld:pubmed |
| pubmed-article:1517567 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1517567 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1517567 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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