Linked Life Data

15174120

Source:http://linkedlifedata.com/resource/pubmed/id/15174120

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-6-2
pubmed:abstractText
The polymerization of epsilon-caprolactone (epsilon-CL) was initiated by the terminal alcohol of methoxy poly(ethylene glycol) (MPEG) as an initiator via activated ring-opening polymerization in the presence of HCl. Et2O as a monomer activator. The molecular weights of the poly(epsilon-caprolactone) (PCL) in MPEG-PCL diblock copolymers controlled with the feed ratio of epsilon-CL to MPEG. The polymerization was preceded by living fashion with no termination or chain transfer. This polymerization procedure offered MPEG-PCL diblock copolymers with well-defined structures. The gel-to-sol transitions of MPEG-PCL diblock copolymer solutions were also examined. The diblock copolymers synthesized with various MPEG and PCL lengths were dissolved in water at 80 degrees C in various concentrations. The polymer solutions formed gel at room temperature. The formed gel became fluids again by increasing the temperature. The gel-to-sol transition showed strong dependence on the length of the MPEG and PCL diblock segments. When the polymer solution was injected into rat, it became a gel at body temperature. The formed gel maintained for 1 month. We confirmed that MPEG-PCL diblock copolymers with well-defined structures served as new thermo-sensitive biomaterials.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1549-3296
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Wiley Periodicals, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
154-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Preparation of poly(ethylene glycol)-block-poly(caprolactone) copolymers and their applications as thermo-sensitive materials.
pubmed:affiliation
Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong, Daejeon 305-600, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't