| pubmed-article:15173192 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15173192 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:15173192 | lifeskim:mentions | umls-concept:C0020275 | lld:lifeskim |
| pubmed-article:15173192 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:15173192 | lifeskim:mentions | umls-concept:C0040557 | lld:lifeskim |
| pubmed-article:15173192 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:15173192 | lifeskim:mentions | umls-concept:C1621574 | lld:lifeskim |
| pubmed-article:15173192 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15173192 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15173192 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:15173192 | pubmed:dateCreated | 2004-6-8 | lld:pubmed |
| pubmed-article:15173192 | pubmed:abstractText | Calcium is a critical mediator of many intracellular processes in eukaryotic cells. In the obligate intracellular parasite Toxoplasma gondii, for example, a rise in [Ca2+] is associated with significant morphological changes and rapid egress from host cells. To understand the mechanisms behind such dramatic effects, we isolated a mutant that is altered in its responses to the Ca2+ ionophore A23187 and found the affected gene encodes a homologue of Na+/H+ exchangers (NHEs) located on the parasite's plasma membrane. We show that in the absence of TgNHE1, Toxoplasma is resistant to ionophore-induced egress and extracellular death and amiloride-induced proton efflux inhibition. In addition, the mutant has increased levels of intracellular Ca2+, which explains its decreased sensitivity to A23187. These results provide direct genetic evidence of a role for NHE1 in Ca2+ homeostasis and important insight into how this ubiquitous pathogen senses and responds to changes in its environment. | lld:pubmed |
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| pubmed-article:15173192 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15173192 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15173192 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15173192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15173192 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15173192 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15173192 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:15173192 | pubmed:author | pubmed-author:BoothroydJohn... | lld:pubmed |
| pubmed-article:15173192 | pubmed:author | pubmed-author:ArrizabalagaG... | lld:pubmed |
| pubmed-article:15173192 | pubmed:author | pubmed-author:MorenoSilviaS | lld:pubmed |
| pubmed-article:15173192 | pubmed:author | pubmed-author:RuizFelixF | lld:pubmed |
| pubmed-article:15173192 | pubmed:copyrightInfo | Copyright the Rockefeller University Press | lld:pubmed |
| pubmed-article:15173192 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15173192 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:15173192 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:15173192 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15173192 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15173192 | pubmed:pagination | 653-62 | lld:pubmed |
| pubmed-article:15173192 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:meshHeading | pubmed-meshheading:15173192... | lld:pubmed |
| pubmed-article:15173192 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15173192 | pubmed:articleTitle | Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation. | lld:pubmed |
| pubmed-article:15173192 | pubmed:affiliation | Department of Microbiology and Immunology, Fairchild Building D305, 300 Pasteur Dr., Stanford University School of Medicine, Stanford, CA 94305-5124, USA. | lld:pubmed |
| pubmed-article:15173192 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15173192 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
