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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2004-6-2
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pubmed:abstractText |
Despite excellent radionuclide characteristics, no (18)F-labeled peptides are available for quantitative peptide receptor mapping using positron emission tomography (PET) so far, mainly due to time-consuming multistep radiosyntheses with limited overall yields. A newly developed two-step chemoselective conjugation method allows rapid and high-yield [(18)F]fluorination of peptides via oxime formation and was applied for the synthesis of new (18)F-labeled carbohydrated Tyr(3)-octreotate (TOCA) analogs with optimized pharmacokinetics suitable for clinical routine somatostatin-receptor (sst) imaging.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3593-606
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15173065-Animals,
pubmed-meshheading:15173065-CHO Cells,
pubmed-meshheading:15173065-Cell Line, Tumor,
pubmed-meshheading:15173065-Chromatography, High Pressure Liquid,
pubmed-meshheading:15173065-Cricetinae,
pubmed-meshheading:15173065-Dose-Response Relationship, Drug,
pubmed-meshheading:15173065-Fluorine Radioisotopes,
pubmed-meshheading:15173065-Fluorodeoxyglucose F18,
pubmed-meshheading:15173065-Glucose,
pubmed-meshheading:15173065-Glycosylation,
pubmed-meshheading:15173065-Inhibitory Concentration 50,
pubmed-meshheading:15173065-Kinetics,
pubmed-meshheading:15173065-Magnetic Resonance Spectroscopy,
pubmed-meshheading:15173065-Models, Chemical,
pubmed-meshheading:15173065-Neoplasms,
pubmed-meshheading:15173065-Oximes,
pubmed-meshheading:15173065-Peptides,
pubmed-meshheading:15173065-Positron-Emission Tomography,
pubmed-meshheading:15173065-Radiopharmaceuticals,
pubmed-meshheading:15173065-Rats,
pubmed-meshheading:15173065-Receptors, Somatostatin,
pubmed-meshheading:15173065-Time Factors,
pubmed-meshheading:15173065-Tissue Distribution,
pubmed-meshheading:15173065-Transfection
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pubmed:year |
2004
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pubmed:articleTitle |
First (18)F-labeled tracer suitable for routine clinical imaging of sst receptor-expressing tumors using positron emission tomography.
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pubmed:affiliation |
Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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