Source:http://linkedlifedata.com/resource/pubmed/id/15172100
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2004-6-2
|
| pubmed:abstractText |
A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes, including the activation of inflammatory cytokines. We performed a case-control association study between sporadic AD patients and the exon 5 position +3953 polymorphism in the potent pro-inflammatory cytokine, interleukin-1beta (IL-1B). Recent association studies of this locus with AD revealed conflicting results, suggesting that the association - if it exists - is not universal but rather population specific. In our study no association was detected with AD: neither as a risk factor nor as a modifier gene affecting the age at onset and disease progression. These findings show no evidence for an association between the IL-1B +3953 polymorphism and AD in the Jewish population.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
363
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
131-3
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:15172100-Age of Onset,
pubmed-meshheading:15172100-Aged,
pubmed-meshheading:15172100-Alzheimer Disease,
pubmed-meshheading:15172100-Apolipoprotein E4,
pubmed-meshheading:15172100-Apolipoproteins E,
pubmed-meshheading:15172100-Case-Control Studies,
pubmed-meshheading:15172100-Chromosome Mapping,
pubmed-meshheading:15172100-DNA Mutational Analysis,
pubmed-meshheading:15172100-Disease Progression,
pubmed-meshheading:15172100-Encephalitis,
pubmed-meshheading:15172100-Female,
pubmed-meshheading:15172100-Genetic Predisposition to Disease,
pubmed-meshheading:15172100-Genetic Testing,
pubmed-meshheading:15172100-Humans,
pubmed-meshheading:15172100-Interleukin-1,
pubmed-meshheading:15172100-Jews,
pubmed-meshheading:15172100-Male,
pubmed-meshheading:15172100-Middle Aged,
pubmed-meshheading:15172100-Mutation,
pubmed-meshheading:15172100-Polymorphism, Genetic,
pubmed-meshheading:15172100-Risk Factors
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Lack of association of interleukin-1beta polymorphism with Alzheimer's disease in the Jewish population.
|
| pubmed:affiliation |
The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Jerusalem, Israel. rosenman@hadassah.org.il
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|