Linked Life Data

15171477

Source:http://linkedlifedata.com/resource/pubmed/id/15171477

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-6-2
pubmed:abstractText
The effects of reprocessing upon hemodialysis have been debated since the introduction of this practice. The objective of this study was to develop a quantitative understanding of the effects of bleach reprocessing upon Fresenius polysulfone dialyzers. Data were obtained for the clearance of urea, vitamin B12, and polydisperse dextrans before and after reprocessing, both with and without exposure to plasma in a simulated dialysis session. Bleach reprocessing of the native dialyzer caused a significant increase in solute clearance because of the removal of polyvinylpyrrolidone from the membrane copolymer. This was confirmed by zeta potential measurements that showed a substantial increase in the negative charge on the membrane surface. Exposure to plasma proteins during hemodialysis effectively protected the dialyzer from chemical degradation by the bleach, with only small changes in solute clearance after the optimal reprocessing cycle. However, inadequate exposure to bleach was unable to restore the original solute clearance while over cleaning with bleach caused an increase in clearance. Considerable care must be taken in the proper design of reprocessing cycles for hemodialysis membranes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1058-2916
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
246-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Effect of bleach reprocessing upon the clearance characteristics and surface charge of polysulfone hemodialyzers.
pubmed:affiliation
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't