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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0022714,
umls-concept:C0034693,
umls-concept:C0035696,
umls-concept:C0085355,
umls-concept:C0185117,
umls-concept:C0332307,
umls-concept:C0597357,
umls-concept:C0597719,
umls-concept:C1367469,
umls-concept:C1522496,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2004-6-1
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pubmed:abstractText |
mRNA levels of kinin B1 and B2 receptors were determined in HPA axis of type 1 (STZ-induced) and type 2 diabetic rats (ZDF and obese Zucker rats). B2 mRNA levels were elevated in hypothalamus of STZ-induced diabetic (STZ-D) and ZDF rats. Pituitary B2 mRNA levels were elevated in ZDF and obese rats. Adrenal B2 mRNA level was attenuated in STZ-D rats. Kinin B1 receptor may not play a role in HPA axis in diabetes since its expression was unchanged. Enhanced mRNA expression of B2 receptors in hypothalamus of STZ-D and ZDF rats parallels a rise in plasma glucose and reflect a functional relationship. Enhanced pituitary B2 mRNA in type 2 and reduced adrenal in type 1 diabetes account for a differential pattern in release of transmitters.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1567-5769
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
571-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15171237-Animals,
pubmed-meshheading:15171237-Blood Glucose,
pubmed-meshheading:15171237-Body Weight,
pubmed-meshheading:15171237-Diabetes Mellitus, Experimental,
pubmed-meshheading:15171237-Diabetes Mellitus, Type 1,
pubmed-meshheading:15171237-Diabetes Mellitus, Type 2,
pubmed-meshheading:15171237-Hypothalamo-Hypophyseal System,
pubmed-meshheading:15171237-Insulin,
pubmed-meshheading:15171237-Leptin,
pubmed-meshheading:15171237-Male,
pubmed-meshheading:15171237-Pituitary-Adrenal System,
pubmed-meshheading:15171237-RNA, Messenger,
pubmed-meshheading:15171237-Rats,
pubmed-meshheading:15171237-Rats, Sprague-Dawley,
pubmed-meshheading:15171237-Rats, Zucker,
pubmed-meshheading:15171237-Receptor, Bradykinin B1,
pubmed-meshheading:15171237-Receptor, Bradykinin B2,
pubmed-meshheading:15171237-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2004
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pubmed:articleTitle |
Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats.
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pubmed:affiliation |
Institute of Experimental and Clinical Pharmacology and Toxicolgy, University Clinic of Schleswig-Holstein, Lübeck, Germany. qadri@medinf.mu-luebeck.de
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pubmed:publicationType |
Journal Article,
Comparative Study
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