Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-6-1
pubmed:abstractText
As little is known about the natural history of bronchial responsiveness and the development of wheezing symptoms in early childhood, a cohort of children at risk of allergy, whose lung function and bronchial responsiveness had been measured in the neonatal period, was followed prospectively for 10 (SD, 0.8) years in order to determine the role of neonatal measurements on wheezing history and later lung function. A potential role for beta-2 adrenoceptor (beta2AR) polymorphisms in these relationships was also sought as a secondary objective. Of the original 73 children, wheezing history was available in 65 (89%), and 49 (67%) attended the laboratory for physiological measurements and genotyping of beta2AR. Wheezing was categorized as occurring 1) only before the fourth birthday, 2) after the fourth birthday, or 3) never. No relation was seen between neonatal and later lung function. However, neonatal bronchial responsiveness predicted subsequent FEV1 (P = 0.03). Increased neonatal bronchial responsiveness was associated with transient wheeze <4 years but not with later wheeze. Neonatal V'maxFRC was reduced in those possessing Gln27 or Arg16 alleles, but there was no effect of beta2AR polymorphisms on FEV1 at 10 years. Wheeze after 4 years of age was typical of classical asthma, as it was strongly related to atopy and bronchial responsiveness at age 10. In conclusion, we confirmed the association of neonatal bronchial responsiveness with both early wheezing and later lung function. We also showed an influence of polymorphisms at both aa16 and aa27 on neonatal lung function. Wheezing beyond 4 years, typical of classical asthma, was unrelated to early measurements of lung function or bronchial responsiveness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
8755-6863
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-81
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:15170877-Analysis of Variance, pubmed-meshheading:15170877-Asthma, pubmed-meshheading:15170877-Bronchial Provocation Tests, pubmed-meshheading:15170877-Child, pubmed-meshheading:15170877-Child, Preschool, pubmed-meshheading:15170877-Child Development, pubmed-meshheading:15170877-Cohort Studies, pubmed-meshheading:15170877-Confidence Intervals, pubmed-meshheading:15170877-Female, pubmed-meshheading:15170877-Follow-Up Studies, pubmed-meshheading:15170877-Humans, pubmed-meshheading:15170877-Infant, pubmed-meshheading:15170877-Infant, Newborn, pubmed-meshheading:15170877-Male, pubmed-meshheading:15170877-Odds Ratio, pubmed-meshheading:15170877-Polymorphism, Genetic, pubmed-meshheading:15170877-Predictive Value of Tests, pubmed-meshheading:15170877-Prospective Studies, pubmed-meshheading:15170877-Receptors, Adrenergic, beta, pubmed-meshheading:15170877-Reference Values, pubmed-meshheading:15170877-Respiratory Function Tests, pubmed-meshheading:15170877-Respiratory Hypersensitivity, pubmed-meshheading:15170877-Respiratory Mechanics, pubmed-meshheading:15170877-Respiratory Physiological Phenomena, pubmed-meshheading:15170877-Respiratory Sounds, pubmed-meshheading:15170877-Time Factors
pubmed:year
2004
pubmed:articleTitle
Symptoms, lung function, and beta2-adrenoceptor polymorphisms in a birth cohort followed for 10 years.
pubmed:affiliation
Department of Paediatrics, National Heart and Lung Institute, London, UK. n.wilson@rbh.nthames.nhs.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't