Source:http://linkedlifedata.com/resource/pubmed/id/15170836
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2004-6-1
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| pubmed:abstractText |
There is growing interest in delivering cellular agents to infarcted myocardium to prevent postinfarction left ventricular remodeling. MRI can be effectively used to differentiate infarcted from healthy myocardium. MR-guided delivery of cellular agents/therapeutics is appealing because the therapeutics can be precisely targeted to the desired location within the infarct. In this study, a steerable intramyocardial injection catheter that can be actively tracked under MRI was developed and tested. The components of the catheter were arranged to form a loopless RF antenna receiver coil that enabled active tracking. Feasibility studies were performed in canine and porcine myocardial infarction models. Myocardial delayed-enhancement (MDE) imaging identified the infarcted myocardium, and real-time MRI was used to guide left ventricular catheterization from a carotid artery approach. The distal 35 cm of the catheter was seen under MRI with a bright signal at the distal tip of the catheter. The catheter was steered into position, the distal tip was apposed against the infarct, the needle was advanced, and a bolus of MR contrast agent and tissue marker dye was injected intramyocardially, as confirmed by imaging and postmortem histology. A pilot study involving intramyocardial delivery of magnetically labeled stem cells demonstrated the utility of the active injection catheter system.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Contrast Media,
http://linkedlifedata.com/resource/pubmed/chemical/Dextrans,
http://linkedlifedata.com/resource/pubmed/chemical/Ferumoxytol,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Magnetite Nanoparticles,
http://linkedlifedata.com/resource/pubmed/chemical/Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/ferumoxides
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
0740-3194
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2004 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:volume |
51
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1163-72
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15170836-Animals,
pubmed-meshheading:15170836-Catheterization,
pubmed-meshheading:15170836-Contrast Media,
pubmed-meshheading:15170836-Dextrans,
pubmed-meshheading:15170836-Dogs,
pubmed-meshheading:15170836-Equipment Design,
pubmed-meshheading:15170836-Ferumoxytol,
pubmed-meshheading:15170836-Heart Catheterization,
pubmed-meshheading:15170836-Injections, Intralesional,
pubmed-meshheading:15170836-Iron,
pubmed-meshheading:15170836-Magnetic Resonance Imaging,
pubmed-meshheading:15170836-Magnetite Nanoparticles,
pubmed-meshheading:15170836-Mesenchymal Stem Cell Transplantation,
pubmed-meshheading:15170836-Myocardial Infarction,
pubmed-meshheading:15170836-Myocardium,
pubmed-meshheading:15170836-Oxides,
pubmed-meshheading:15170836-Phantoms, Imaging,
pubmed-meshheading:15170836-Swine
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| pubmed:year |
2004
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| pubmed:articleTitle |
MR-trackable intramyocardial injection catheter.
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| pubmed:affiliation |
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025, USA. pkarmar@mri.jhu.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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