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pubmed-article:15169554pubmed:abstractTextWe previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41. The modified Env protein antigenically mimics the functional wild-type Env complex. Here, we explore the effects of the covalent gp120 - gp41 interaction on virus replication and evolution.lld:pubmed
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pubmed-article:15169554pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:15169554pubmed:articleTitleEvolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41.lld:pubmed
pubmed-article:15169554pubmed:affiliationDept. of Human Retrovirology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. r.w.sanders@amc.uva.nllld:pubmed
pubmed-article:15169554pubmed:publicationTypeJournal Articlelld:pubmed
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