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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2004-5-28
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pubmed:abstractText |
Whole-cell recordings were performed on rat trigeminal ganglion (TG) neurons as a modeling experiment to investigate the effect of bis (7)-tacrine, a potential anti-Alzheimer's disease (AD) drug, on 5-HT-induced current (I5-HT). Extracellular 5-HT activated a concentration-dependent inward current that was blocked by ICS 205930. Co-application of bis(7)-tacrine inhibited I5-HT markedly with IC50 at 2 x 10 M. Bis(7)-tacrine shifted the concentration-response curve for I5-HT rightwards with its maximum response unchanged and EC50 increased, suggesting that this inhibition was competitive in nature. Intracellular dialysis of GDP-beta-S did not block bis(7)-tacrine inhibition of I5-HT, which excluded the involvement of G-protein mediation. These results may offer possible modality to understanding the anti-AD mechanism of bis(7)-tacrine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,7-N-heptylene-bis-9,9'-amino-1,2,3...,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrine,
http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/guanosine 5'-O-(2-thiodiphosphate)
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 Lippincott Williams and Wilkins
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1335-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15167561-Alzheimer Disease,
pubmed-meshheading:15167561-Animals,
pubmed-meshheading:15167561-Cell Membrane,
pubmed-meshheading:15167561-Cells, Cultured,
pubmed-meshheading:15167561-Dose-Response Relationship, Drug,
pubmed-meshheading:15167561-Drug Interactions,
pubmed-meshheading:15167561-GTP-Binding Proteins,
pubmed-meshheading:15167561-Guanosine Diphosphate,
pubmed-meshheading:15167561-Membrane Potentials,
pubmed-meshheading:15167561-Neural Inhibition,
pubmed-meshheading:15167561-Neurons,
pubmed-meshheading:15167561-Patch-Clamp Techniques,
pubmed-meshheading:15167561-Rats,
pubmed-meshheading:15167561-Rats, Sprague-Dawley,
pubmed-meshheading:15167561-Receptors, Serotonin,
pubmed-meshheading:15167561-Serotonin,
pubmed-meshheading:15167561-Serotonin Antagonists,
pubmed-meshheading:15167561-Synaptic Transmission,
pubmed-meshheading:15167561-Tacrine,
pubmed-meshheading:15167561-Thionucleotides,
pubmed-meshheading:15167561-Trigeminal Ganglion
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pubmed:year |
2004
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pubmed:articleTitle |
Inhibition by bis(7)-tacrine of 5-HT-activated current in rat TG neurons.
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pubmed:affiliation |
Department of Molecular and Cellular Neurobiology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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