Linked Life Data

15167284

Source:http://linkedlifedata.com/resource/pubmed/id/15167284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-5-28
pubmed:abstractText
The transmission of HIV-1 from mother to child during pregnancy is unlike other types of HIV-1 transmission because the child shares major histocompatibility complex (MHC) genes with the mother during a time while the mother is induced to tolerate the paternally derived fetal MHC molecules, in part through natural killer (NK) recognition of MHC polymorphisms. The relevance of these immune mechanisms to HIV-1 transmission was assessed by determining the HLA-B alleles of mother and infant. Almost half (48%) of mothers who transmitted with low viral loads had HLA-B*1302, B*3501, B*3503, B*4402, or B*5001 alleles, compared with 8% of nontransmitting mothers (P=0.001). Conversely, 25% of mothers who did not transmit despite high viral loads had B*4901 and B*5301, vs. 5% of transmitting mothers (P=0.003), a pattern of allelic involvement distinct from that influencing HIV-1 infection outcome. The infant's HLA-B alleles did not appear associated with transmission risk. The HLA-B*4901 and B*5301 alleles that were protective in the mother both differed respectively from the otherwise identical susceptibility alleles, B*5001 and B*3501, by 5 amino acids encoding the ligand for the KIR3DL1 NK receptor. These results suggest that the probable molecular basis of the observed association involves definition of the maternal NK recognition repertoire by engagement of NK receptors with polymorphic ligands encoded by maternal HLA-B alleles, and that the placenta is the likely site of the effect that appears to protect against transmission of maternal HIV-1 through interrelating adaptive and innate immune recognition.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1525-4135
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
659-70
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:15167284-Adolescent, pubmed-meshheading:15167284-Adult, pubmed-meshheading:15167284-Alleles, pubmed-meshheading:15167284-Base Sequence, pubmed-meshheading:15167284-Case-Control Studies, pubmed-meshheading:15167284-Cohort Studies, pubmed-meshheading:15167284-DNA, pubmed-meshheading:15167284-Female, pubmed-meshheading:15167284-Gene Frequency, pubmed-meshheading:15167284-HIV Infections, pubmed-meshheading:15167284-HIV-1, pubmed-meshheading:15167284-HLA-B Antigens, pubmed-meshheading:15167284-Humans, pubmed-meshheading:15167284-Immunity, Innate, pubmed-meshheading:15167284-Infant, Newborn, pubmed-meshheading:15167284-Infectious Disease Transmission, Vertical, pubmed-meshheading:15167284-Male, pubmed-meshheading:15167284-Models, Molecular, pubmed-meshheading:15167284-Pregnancy, pubmed-meshheading:15167284-Prospective Studies, pubmed-meshheading:15167284-Receptors, Immunologic, pubmed-meshheading:15167284-Receptors, KIR, pubmed-meshheading:15167284-Receptors, KIR3DL1
pubmed:year
2004
pubmed:articleTitle
Mother-to-child transmission of HIV-1: strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanisms.
pubmed:affiliation
Columbia University, Department of Pediatrics, New York, NY 10032, USA. rjw8@columbia.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Multicenter Study, Research Support, N.I.H., Extramural