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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-5-28
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pubmed:abstractText |
This report describes a 49-year-old woman with a well-circumscribed nodule of liposarcoma. The patient noticed a soft, slowly growing mass at the right sural region. Both axial computed tomography and magnetic resonance imaging revealed a soft tissue tumor consisting of nonfatty lesion measuring 5 x 3 x 3 cm circumscribed by a 1-cm thickened fatty area. Histologically, the tumor was made of 2 distinct components: the inner component of the tumor was a classic myxoid liposarcoma with numerous lipoblasts; the outer component was a lipoma-like lesion consisting of mature adipocytes without atypical nuclei. Immunohistochemically, MDM2 overexpression was observed and p53 immunophenotype was negative in both components. Molecular analysis revealed that type 1 TLS/ CHOP fusion gene transcript, characteristic of myxoid/round cell liposarcoma, was detected in both areas.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MDM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-mdm2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Protein FUS,
http://linkedlifedata.com/resource/pubmed/chemical/TLS-CHOP fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor CHOP,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1052-9551
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
92-6
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15167010-Adipocytes,
pubmed-meshheading:15167010-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:15167010-Female,
pubmed-meshheading:15167010-Humans,
pubmed-meshheading:15167010-Immunohistochemistry,
pubmed-meshheading:15167010-Ki-67 Antigen,
pubmed-meshheading:15167010-Leg,
pubmed-meshheading:15167010-Liposarcoma, Myxoid,
pubmed-meshheading:15167010-Middle Aged,
pubmed-meshheading:15167010-Nuclear Proteins,
pubmed-meshheading:15167010-Oncogene Proteins, Fusion,
pubmed-meshheading:15167010-Proto-Oncogene Proteins,
pubmed-meshheading:15167010-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:15167010-RNA-Binding Protein FUS,
pubmed-meshheading:15167010-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15167010-Soft Tissue Neoplasms,
pubmed-meshheading:15167010-Tomography, X-Ray Computed,
pubmed-meshheading:15167010-Transcription Factor CHOP,
pubmed-meshheading:15167010-Tumor Suppressor Protein p53
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pubmed:year |
2004
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pubmed:articleTitle |
Myxoid liposarcoma with adipocytic maturation: detection of TLS/CHOP fusion gene transcript.
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pubmed:affiliation |
Departments of Orthopedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. h-nakanishi@mvf.biglobe.ne.jp
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pubmed:publicationType |
Journal Article,
Case Reports
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