|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1992-10-8
|
|
pubmed:abstractText |
The oxadiazole L-687,306 is a high affinity muscarinic agonist with a N-methylscopolamine/oxotremorine-M binding profile predictive of a partial agonist. L-687,306 showed marked selectivity in functional pharmacological assays. L-687,306 was a partial agonist at muscarinic M1 receptors in the rat ganglion but a high affinity competitive antagonist at guinea-pig cardiac M2 and ileal M3 muscarinic receptors. This compound gives an opportunity to study receptor reserve involved in muscarinic receptors in vitro and in vivo.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0014-2999
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
29
|
|
pubmed:volume |
215
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
135-6
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1516645-Animals,
pubmed-meshheading:1516645-Bicyclo Compounds,
pubmed-meshheading:1516645-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:1516645-Ganglia, Spinal,
pubmed-meshheading:1516645-Guinea Pigs,
pubmed-meshheading:1516645-Muscarine,
pubmed-meshheading:1516645-Myenteric Plexus,
pubmed-meshheading:1516645-Neuromuscular Junction,
pubmed-meshheading:1516645-Oxadiazoles,
pubmed-meshheading:1516645-Rats,
pubmed-meshheading:1516645-Receptors, Muscarinic
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
L-687,306: a functionally selective and potent muscarinic M1 receptor agonist.
|
|
pubmed:affiliation |
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
