Linked Life Data

1516412

Source:http://linkedlifedata.com/resource/pubmed/id/1516412

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-10-7
pubmed:abstractText
Exercise intolerance and exertional dyspnea are common complaints in patients with sarcoidosis. Although in many cases these complaints are attributable to restrictive or obstructive lung mechanics or inefficiency of pulmonary gas exchange, other processes also may contribute to impairment in exercise function and may not be readily detected or distinguished from problems of lung mechanics on the basis of symptoms or routine laboratory testing. To identify the frequency and etiology of impaired exercise capacity in sarcoidosis patients with mild lung disease, integrative cardiopulmonary exercise testing was performed in 23 patients. Breath-by-breath measurements were made of gas exchange, ventilation, and heart rate. In 9 of 20 evaluable patients, the oxygen uptake (VO2) at the anaerobic threshold was low, and/or the rate of increase of VO2 was abnormal relative to work rate or heart rate, suggesting a defect in cardiocirculatory function. Resting and exercise echocardiography revealed normal left ventricular ejection fractions and wall motion in all nine of these patients, but findings suggestive of right ventricular hypertrophy and/or right ventricular dysfunction were present in five. Abnormal responses of VO2 during exercise are common in patients with sarcoidosis and may be due to subclinical impairment of right-sided cardiac function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0012-3692
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
838-45
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Abnormal oxygen uptake responses to exercise in patients with mild pulmonary sarcoidosis.
pubmed:affiliation
Department of Medicine, Harbor-UCLA Medical Center, Torrance 90502.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.