Source:http://linkedlifedata.com/resource/pubmed/id/15163120
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2004-5-27
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| pubmed:abstractText |
Several populational-based studies have suggested an association between tumoral necrosis factor-alpha (TNF-alpha) polymorphisms and obesity-related phenotypes. Therefore, this study aimed at assessing the situation (frequency and associated phenotype) of two TNF-alpha common polymorphisms in a Spanish population. In a case-control design study, a group of Spanish subjects (n=313) were genotyped for the TNF-alpha G/A -308 and -238 polymorphisms. Obese subjects (cases) were compared with lean individuals (controls) according to body mass index (BMI; cases: BMI >30 kg/m2, controls: BMI <25 kg/m2). Waist-to-hip ratio, body composition and some metabolic indicators were assessed. The frequency of the -308A allele (0.14) and -238A allele (0.09) was similar to those previously reported in other Caucasian populations. Interestingly, cases with the -308A allele of the TNF-alpha gene have significantly higher hip and waist circumferences (p<0.05), BMI (p<0.01) and body fat mass (p<0.05) values than obese individuals carrying the -308G allele, but not the waist-to-hip ratio. No apparent influence of the -308A polymorphism on other metabolic indicators (insulin and leptin levels) was found. We could not detect any association between the substitution at position -238 polymorphism of the TNF-alpha gene and obesity anthropometrical phenotypes in this Spanish population, despite some differences in plasma leptin. These results support the hypothesis that the G/A -308 polymorphism of the TNF-alpha gene is associated with a higher BMI as well as hip ad waist circumferences, particularly on female bearers, while no influence on such measurements was found for the G/A -238 TNF-alpha gene polymorphism, but only an effect on leptinaemia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0394-3402
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
17
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
17-22
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:15163120-Adult,
pubmed-meshheading:15163120-Alleles,
pubmed-meshheading:15163120-Body Composition,
pubmed-meshheading:15163120-Body Constitution,
pubmed-meshheading:15163120-Body Mass Index,
pubmed-meshheading:15163120-Case-Control Studies,
pubmed-meshheading:15163120-Female,
pubmed-meshheading:15163120-Gene Frequency,
pubmed-meshheading:15163120-Genotype,
pubmed-meshheading:15163120-Humans,
pubmed-meshheading:15163120-Insulin,
pubmed-meshheading:15163120-Leptin,
pubmed-meshheading:15163120-Male,
pubmed-meshheading:15163120-Middle Aged,
pubmed-meshheading:15163120-Obesity,
pubmed-meshheading:15163120-Phenotype,
pubmed-meshheading:15163120-Polymorphism, Genetic,
pubmed-meshheading:15163120-Promoter Regions, Genetic,
pubmed-meshheading:15163120-Sex Factors,
pubmed-meshheading:15163120-Spain,
pubmed-meshheading:15163120-Tumor Necrosis Factor-alpha
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| pubmed:year |
2004
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| pubmed:articleTitle |
Influence of two polymorphisms of the tumoral necrosis factor-alpha gene on the obesity phenotype.
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| pubmed:affiliation |
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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