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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
11
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pubmed:dateCreated |
2004-5-26
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pubmed:abstractText |
The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occurring (-)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
|
pubmed:issn |
1477-0520
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
2
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1592-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15162210-Catalysis,
pubmed-meshheading:15162210-Crystallography, X-Ray,
pubmed-meshheading:15162210-Cyclohexanecarboxylic Acids,
pubmed-meshheading:15162210-Cyclohexenes,
pubmed-meshheading:15162210-Enzyme Inhibitors,
pubmed-meshheading:15162210-Hydro-Lyases,
pubmed-meshheading:15162210-Models, Molecular,
pubmed-meshheading:15162210-Molecular Structure,
pubmed-meshheading:15162210-Mycobacterium tuberculosis
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pubmed:year |
2004
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|
pubmed:articleTitle |
(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases.
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|
pubmed:affiliation |
University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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