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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2004-5-26
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pubmed:abstractText |
Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with a decrease in the risk of several cancers, including breast cancer. NSAIDs inhibit cyclooxygenase activity and thereby reduce prostaglandin synthesis; prostaglandins stimulate aromatase gene expression and thereby stimulate estrogen biosynthesis. Given the importance of estrogen in the pathogenesis of breast cancer, the ability of aspirin and other NSAIDs to protect against breast cancer could vary according to hormone receptor status.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1538-3598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
26
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pubmed:volume |
291
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2433-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15161893-Adult,
pubmed-meshheading:15161893-Aged,
pubmed-meshheading:15161893-Aged, 80 and over,
pubmed-meshheading:15161893-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15161893-Anticarcinogenic Agents,
pubmed-meshheading:15161893-Aspirin,
pubmed-meshheading:15161893-Breast Neoplasms,
pubmed-meshheading:15161893-Case-Control Studies,
pubmed-meshheading:15161893-Female,
pubmed-meshheading:15161893-Humans,
pubmed-meshheading:15161893-Middle Aged,
pubmed-meshheading:15161893-Receptors, Estrogen,
pubmed-meshheading:15161893-Receptors, Progesterone,
pubmed-meshheading:15161893-Risk Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk.
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pubmed:affiliation |
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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