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rdf:type |
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lifeskim:mentions |
umls-concept:C0002475,
umls-concept:C0006142,
umls-concept:C0013089,
umls-concept:C0016360,
umls-concept:C0205179,
umls-concept:C0249197,
umls-concept:C0288472,
umls-concept:C0314603,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0683598,
umls-concept:C1420626,
umls-concept:C1516924,
umls-concept:C1517927
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pubmed:issue |
10
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pubmed:dateCreated |
2004-5-26
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pubmed:abstractText |
The cyclin-dependent kinase inhibitor p21 acts as a main executor of p53-induced growth arrest. Recently, a second transcript, p21B, was found to code for a protein expressing proapoptotic activity. We investigated p21 and p21B for mutations and epigenetic silencing in locally advanced breast cancers treated with doxorubicin or 5-fluorouracil/mitomycin and correlated our findings with treatment response and TP53 status.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil,
http://linkedlifedata.com/resource/pubmed/chemical/HRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins p21(ras),
http://linkedlifedata.com/resource/pubmed/chemical/RAP2B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/rap GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3438-43
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15161699-Antibiotics, Antineoplastic,
pubmed-meshheading:15161699-Antimetabolites, Antineoplastic,
pubmed-meshheading:15161699-Breast Neoplasms,
pubmed-meshheading:15161699-Cell Line, Tumor,
pubmed-meshheading:15161699-Cloning, Molecular,
pubmed-meshheading:15161699-DNA Methylation,
pubmed-meshheading:15161699-DNA Primers,
pubmed-meshheading:15161699-Doxorubicin,
pubmed-meshheading:15161699-Drug Resistance, Neoplasm,
pubmed-meshheading:15161699-Fluorouracil,
pubmed-meshheading:15161699-Gene Silencing,
pubmed-meshheading:15161699-Humans,
pubmed-meshheading:15161699-Immunohistochemistry,
pubmed-meshheading:15161699-Lymphocytes,
pubmed-meshheading:15161699-Mitomycin,
pubmed-meshheading:15161699-Models, Genetic,
pubmed-meshheading:15161699-Polymorphism, Genetic,
pubmed-meshheading:15161699-Promoter Regions, Genetic,
pubmed-meshheading:15161699-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:15161699-RNA,
pubmed-meshheading:15161699-RNA, Messenger,
pubmed-meshheading:15161699-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15161699-Sequence Analysis, DNA,
pubmed-meshheading:15161699-Tumor Suppressor Protein p53,
pubmed-meshheading:15161699-rap GTP-Binding Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
Genetic and epigenetic changes in p21 and p21B do not correlate with resistance to doxorubicin or mitomycin and 5-fluorouracil in locally advanced breast cancer.
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pubmed:affiliation |
Department of Medicine, Section of Oncology, Haukeland University Hospital, Bergen, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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