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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2004-5-26
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pubmed:abstractText |
Telomeres help maintain chromosomal integrity. Dysfunctional telomeres can cause genetic instability in vitro and an increased cancer incidence in telomerase knock out mouse models. We recently reported that telomere shortening was a prevalent alteration in human prostate, pancreas, and breast cancer precursor lesions. In the present study, we address whether the previous findings are broadly applicable to human epithelial cancer precursors in general.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3317-26
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15161685-Adult,
pubmed-meshheading:15161685-Aged,
pubmed-meshheading:15161685-Animals,
pubmed-meshheading:15161685-Breast Neoplasms,
pubmed-meshheading:15161685-Chromosome Aberrations,
pubmed-meshheading:15161685-Chromosomes,
pubmed-meshheading:15161685-Colonic Neoplasms,
pubmed-meshheading:15161685-Epithelial Cells,
pubmed-meshheading:15161685-Esophageal Neoplasms,
pubmed-meshheading:15161685-Female,
pubmed-meshheading:15161685-Humans,
pubmed-meshheading:15161685-Image Processing, Computer-Assisted,
pubmed-meshheading:15161685-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15161685-Male,
pubmed-meshheading:15161685-Mice,
pubmed-meshheading:15161685-Mice, Knockout,
pubmed-meshheading:15161685-Middle Aged,
pubmed-meshheading:15161685-Mouth Neoplasms,
pubmed-meshheading:15161685-Neoplasms,
pubmed-meshheading:15161685-Neoplasms, Glandular and Epithelial,
pubmed-meshheading:15161685-Nucleic Acid Hybridization,
pubmed-meshheading:15161685-Prostatic Neoplasms,
pubmed-meshheading:15161685-Telomere,
pubmed-meshheading:15161685-Tumor Markers, Biological,
pubmed-meshheading:15161685-Urinary Bladder Neoplasms,
pubmed-meshheading:15161685-Uterine Cervical Neoplasms
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pubmed:year |
2004
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pubmed:articleTitle |
Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis.
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pubmed:affiliation |
Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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