Linked Life Data

15161233

Source:http://linkedlifedata.com/resource/pubmed/id/15161233

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2004-5-26
pubmed:abstractText
Sugar-casein glycation products (GPs) were generated by Maillard reaction (MR) with different monosaccharide sources [e.g., glucose (Glc), fructose (Fru), and ribose (Rib)] and prolonged heating (e.g., 27 days at 55 degrees C) to produce Maillard reaction products (MRPs) that varied in opponent (L, a, b) color measurement and changes in pH, available lysine, and amino-sugar ratio. Theses results signified different rates of three sugar and casein glycation. Sugar-casein GPs from aldohexose, ketohexose, and aldopentose sugar sources were recovered on day 18 of heating and compared for bioactive properties using human embryonic intestinal cell (Int-407) and adenocarcinoma cell (Caco-2) lines. Glu- and Fru-casein GPs produced significant (p < 0.05) decreases in antioxidant superoxide dismutase (SOD), glutathione peroxidase, and glutathione reductase enzyme activities in the Int-407 cell line, whereas no effect on antioxidant enzymes was obtained from Rib-casein GP. Moreover, the Caco-2 cell antioxidant enzyme status was not affected by the presence of sugar-casein GPs, regardless of sugar source. The reduction in antioxidant enzyme activity of Int-407 cells by Glu and Fru- casein GPs corresponded to a significant (p < 0.05) reduction in Int-407 cell viability. In contrast, no change in Caco-2 cell viability was observed with sugar-casein GP. This finding demonstrates that the noted variable cytotoxic, sugar specific effects of casein GP were related to reductions in critical antioxidant enzyme activities. Moreover, the source of intestinal cell line was an important factor to show the effect of sugar-casein GPs on redox-related cytotoxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-8561
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3577-82
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Redox-related cytotoxic responses to different casein glycation products in Caco-2 and int-407 cells.
pubmed:affiliation
Food, Nutrition and Health, The University of British Columbia, 6640 Northwest Marine Drive, Vancouver, British Columbia V6T 1Z4, Canada.
pubmed:publicationType
Journal Article