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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2B
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pubmed:dateCreated |
2004-5-26
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pubmed:abstractText |
Neuroblastoma (NB) is an aggressive childhood cancer of the peripheral nervous system arising from neural crest sympathoadrenal progenitor cells. Despite current rigorous treatment protocols, prognosis for high stage NB patients is poor and so there remains a need for more effective, less cytotoxic treatments. Curcumin and resveratrol possess anti-tumor properties in adult cancer models and negligible toxicity in normal cells, but little is known about the effect of these agents on pediatric cancers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Curcumin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/MYCN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Stilbenes,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/resveratrol
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
987-98
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15161054-Antineoplastic Agents,
pubmed-meshheading:15161054-Apoptosis,
pubmed-meshheading:15161054-Cell Cycle,
pubmed-meshheading:15161054-Cell Division,
pubmed-meshheading:15161054-Cell Line, Tumor,
pubmed-meshheading:15161054-Cell Nucleus,
pubmed-meshheading:15161054-Curcumin,
pubmed-meshheading:15161054-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:15161054-Cyclins,
pubmed-meshheading:15161054-Dose-Response Relationship, Drug,
pubmed-meshheading:15161054-Humans,
pubmed-meshheading:15161054-Neuroblastoma,
pubmed-meshheading:15161054-Nuclear Proteins,
pubmed-meshheading:15161054-Oncogene Proteins,
pubmed-meshheading:15161054-Proto-Oncogene Proteins,
pubmed-meshheading:15161054-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:15161054-Stilbenes,
pubmed-meshheading:15161054-Transcriptional Activation,
pubmed-meshheading:15161054-Tumor Suppressor Protein p53,
pubmed-meshheading:15161054-Up-Regulation,
pubmed-meshheading:15161054-bcl-2-Associated X Protein
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pubmed:articleTitle |
Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma.
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pubmed:affiliation |
Department of Paediatric Laboratory Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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