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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2B
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pubmed:dateCreated |
2004-5-26
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pubmed:abstractText |
Humans lack the gene alpha 1,3 galactosyltransferase (GalT) and instead produce abundant cytolytic antibodies against cells bearing the antigen [gal alpha1,3 gal] (alphaGal). We have previously studied humoral anti-alphaGal responses in GalT knock-out (GalT KO) mice and shown that murine anti-alphaGal IgM, like human anti-alphaGal IgM, causes extensive complement-mediated cytolysis of GalT+ murine Lewis Lung carcinoma cells (LLCa) in vitro. Here we test the hypothesis that anti-alphaGal immune responses can inhibit the in vivo development of GalT+ tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
605-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15161001-Animals,
pubmed-meshheading:15161001-Antibodies, Neoplasm,
pubmed-meshheading:15161001-Carcinoma, Lewis Lung,
pubmed-meshheading:15161001-Female,
pubmed-meshheading:15161001-Galactosyltransferases,
pubmed-meshheading:15161001-Immunoglobulin G,
pubmed-meshheading:15161001-Immunoglobulin M,
pubmed-meshheading:15161001-Lung Neoplasms,
pubmed-meshheading:15161001-Male,
pubmed-meshheading:15161001-Mice,
pubmed-meshheading:15161001-Mice, Knockout
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|
pubmed:articleTitle |
Suppression of Lewis lung tumor development in alpha 1,3 galactosyltransferase knock-out mice.
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pubmed:affiliation |
Department of Microbiology and Immunology, The Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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