Source:http://linkedlifedata.com/resource/pubmed/id/15160952
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2004-5-26
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pubmed:abstractText |
The goal of this trial was to assess the toxicity and potential efficacy of high-dose topotecan, melphalan and cyclophosphamide as a preparative regimen for patients with multiple myeloma undergoing autologous stem cell transplantation. Eighteen patients were treated, 8 for first remission consolidation, 4 with relapse sensitive disease, 3 primary refractory and 3 relapsed refractory. The median age was 56 (38 - 65) and the median number of prior regimens was 3 (1 - 8). Patients received cyclophosphamide 1 g/m2/d on days -6, -5, -4; melphalan 70 mg/m2 on days -3, -2 and topotecan 3.0 to 3.5 mg/m2/d on days -6 to -2. Peripheral blood stem cells were infused on day 0. Toxicity (Bearman Toxicity Criteria) was mostly limited to grade 1 - 2 mucositis and grade 1 diarrhea. There were no transplant-related deaths. The overall response rate at 3 months post transplantation was 89% with 17% CR, 2 of those in refractory patients. The overall response rate in refractory patients was 67%. With a median follow up of 12.3 months, 89% of patients are alive. The TMC regimen is well tolerated and produces high response rates. Further evaluation of TMC to fully assess response and survival is ongoing.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1042-8194
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
755-9
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:15160952-Adult,
pubmed-meshheading:15160952-Aged,
pubmed-meshheading:15160952-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15160952-Cyclophosphamide,
pubmed-meshheading:15160952-Female,
pubmed-meshheading:15160952-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:15160952-Humans,
pubmed-meshheading:15160952-Male,
pubmed-meshheading:15160952-Melphalan,
pubmed-meshheading:15160952-Middle Aged,
pubmed-meshheading:15160952-Multiple Myeloma,
pubmed-meshheading:15160952-Pilot Projects,
pubmed-meshheading:15160952-Remission Induction,
pubmed-meshheading:15160952-Survival Rate,
pubmed-meshheading:15160952-Topotecan,
pubmed-meshheading:15160952-Transplantation, Autologous,
pubmed-meshheading:15160952-Treatment Outcome
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pubmed:year |
2004
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pubmed:articleTitle |
High-dose topotecan, melphalan and cyclophosphamide (TMC) with stem cell support: a new regimen for the treatment of multiple myeloma.
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pubmed:affiliation |
Department of Blood and Marrow Transplantation, The University of Texas M.D. Anderson Cancer Center, Houston 77030-4095, USA. mdonato@mdanderson.org
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pubmed:publicationType |
Journal Article,
Clinical Trial
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