Source:http://linkedlifedata.com/resource/pubmed/id/15160912
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
2004-5-26
|
pubmed:abstractText |
Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have an increased incidence of high-grade lymphoid malignancy. The risk of non-lymphoid second malignancy in this population is not well-defined to date. To test the hypothesis that patients with CLL/SLL have an increased risk of second malignancy, we studied the rate of second malignancy in 132 CLL/SLL patients and compared it to the rate of malignancy (excluding non-melanomatous skin cancer) in the Central Arkansas Veterans Healthcare System population of approximately 38,000 veterans over a period of 11.5 years. The rate of second malignancy, diagnosed concomitantly or after CLL/SLL, and the age-adjusted rate of malignancy calculated from tumor registry reports and demographic data, were used to calculate a Standardized Morbidity Ratio (SMR) with 95% confidence interval (CI). Twenty-one (16%) of the CLL/SLL patients had second malignancies (19 non-lymphoid, 1 Richter's transformation and 1 Hodgkin's disease), which were fatal in 15 (71%) patients. The SMR for the CLL/SLL population was 2.97 (95% CI 1.84-4.55) for second malignancy and 2.69 (95% CI 1.62-4.21) for non-lymphoid second malignancy. This study of a well-defined CLL/SLL population shows a significantly increased risk of second malignancy, which was the primary cause of death for 9% of all CLL/SLL patients (34% of all patient deaths).
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1042-8194
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
45
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
507-13
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15160912-Adult,
pubmed-meshheading:15160912-Aged,
pubmed-meshheading:15160912-Aged, 80 and over,
pubmed-meshheading:15160912-Cause of Death,
pubmed-meshheading:15160912-Female,
pubmed-meshheading:15160912-Humans,
pubmed-meshheading:15160912-Incidence,
pubmed-meshheading:15160912-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:15160912-Male,
pubmed-meshheading:15160912-Middle Aged,
pubmed-meshheading:15160912-Neoplasms, Second Primary,
pubmed-meshheading:15160912-Risk,
pubmed-meshheading:15160912-Survival Analysis,
pubmed-meshheading:15160912-Veterans
|
pubmed:year |
2004
|
pubmed:articleTitle |
Veterans with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have a markedly increased rate of second malignancy, which is the most common cause of death.
|
pubmed:affiliation |
Division of Hematology/Oncology, Department of Medicine, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
|
pubmed:publicationType |
Journal Article
|