Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2004-7-9
pubmed:abstractText
Based on experimental work and clinical small studies, histidine-tryptophan-ketoglutarate (HTK) solution was found to be suitable not only for heart and kidney preservation but also for liver preservation. We decided, therefore, to use this preservation solution for clinical liver preservation in a prospective multi-centre trial. Enrolment to the study was from 1996 to 1999 in four European centres, and the results of 214 patients with HTK-preserved organs were analysed. Analysis showed a primary dysfunction (PDF) rate of 8.8%, with a primary non-function (PNF) rate of 2.3% and initial poor function (IPF) in 6.5%. Patient survival rate at 1 year was 83% and 1-year graft survival rate was 80%. In a univariate and a multivariate analysis PDF, early surgical complications and tendentiously severe infections (septicaemia, pneumonia, cholangitis) were identified as independent risk factors for graft and patient survival. Preservation with HTK can be regarded as an established alternative to preservation with University of Wisconsin (UW) solution when preservation times are short. Definitive assessment of the efficacy of preservation solutions requires further prospective randomised clinical trials that compare HTK and UW.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0934-0874
pubmed:author
pubmed:copyrightInfo
Copyright 2004 Springer-Verlag
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
256-60
pubmed:meshHeading
pubmed-meshheading:15160235-Drug Therapy, Combination, pubmed-meshheading:15160235-Europe, pubmed-meshheading:15160235-Female, pubmed-meshheading:15160235-Glucose, pubmed-meshheading:15160235-Graft Survival, pubmed-meshheading:15160235-Humans, pubmed-meshheading:15160235-Immunosuppressive Agents, pubmed-meshheading:15160235-Liver Cirrhosis, pubmed-meshheading:15160235-Liver Diseases, pubmed-meshheading:15160235-Liver Neoplasms, pubmed-meshheading:15160235-Liver Transplantation, pubmed-meshheading:15160235-Male, pubmed-meshheading:15160235-Mannitol, pubmed-meshheading:15160235-Middle Aged, pubmed-meshheading:15160235-Organ Preservation Solutions, pubmed-meshheading:15160235-Potassium Chloride, pubmed-meshheading:15160235-Procaine, pubmed-meshheading:15160235-Retrospective Studies, pubmed-meshheading:15160235-Survival Analysis
pubmed:year
2004
pubmed:articleTitle
Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation-a prospective multi-centre observation study.
pubmed:affiliation
Department of Transplant Surgery, University Hospital of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria, h.pokorny@akh-wien.ac.at
pubmed:publicationType
Journal Article, Multicenter Study