Source:http://linkedlifedata.com/resource/pubmed/id/15159311
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2004-5-25
|
| pubmed:abstractText |
Folate and methionine metabolism is involved in DNA synthesis and methylation processes. Polymorphisms in the genes of folate metabolism enzymes have been associated with some forms of cancer. In a case-control study, we evaluated whether four common polymorphisms in methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A2756G), and methionine synthase reductase (MTRR A66G) genes may have a role in altering susceptibility to adult acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL). We analyzed DNA of 120 adult ALL, 200 NHL, and 257 healthy control subjects. Individual carrying the MTHFR 677TT genotype showed a 3.6-fold decreased ALL risk [odds ratio (OR) 0.28, 95% confidence interval (95% CI) 0.12-0.72] than wild-types. Similarly, MS 2756GG individuals showed a 5.0-fold decreased ALL risk (OR 0.20, 95% CI 0.02-1.45) than wild-types. In combined results, subjects with the MTHFR 677CT/TT and MS 2756AG/GG genotypes revealed a 3.6-fold ALL risk reduction (OR 0.28, 95% CI 0.14-0.58) and those with the MTHFR 677TT and MTRR 66AG genotypes revealed a 4.2-fold ALL risk reduction (OR 0.24, 95% CI 0.06-0.81). Finally, those with the MS 2756AG/GG and MTRR 66AG/GG genotypes revealed a 2.2-fold ALL risk reduction (OR 0.45, 95% CI 0.10-0.85). Single analysis for NHL did not show any significant difference for all the polymorphisms investigated, but in the low-grade NHL subgroup, we found a 2.0-fold risk reduction for the MTRR 66GG homozygous genotype (OR 0.50, 95% CI 0.25-0.99), which was higher (OR 0.37, 95% CI 0.14-0.85) when analyzed in combination with MS 2756AA genotype. These data are in accordance with the hypothesis that polymorphisms in the genes for folate and methionine metabolism might play a greater role in the occurrence of ALL than NHL by influencing DNA synthesis and/or DNA methylation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1055-9965
|
| pubmed:author |
pubmed-author:CarusoAngeloA,
pubmed-author:De MatteiMonicaM,
pubmed-author:Della PortaMatteoM,
pubmed-author:Di BonaErosE,
pubmed-author:GemmatiDonatoD,
pubmed-author:GilliGiuseppeG,
pubmed-author:OngaroAlessiaA,
pubmed-author:PaselloMichelaM,
pubmed-author:PellatiAgneseA,
pubmed-author:ReverberiRobertoR,
pubmed-author:RodeghieroFrancescoF,
pubmed-author:ScapoliGian LGL,
pubmed-author:SerinoMaria LML,
pubmed-author:TognazzoSilviaS
|
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
787-94
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15159311-5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase,
pubmed-meshheading:15159311-Adolescent,
pubmed-meshheading:15159311-Adult,
pubmed-meshheading:15159311-Age Distribution,
pubmed-meshheading:15159311-Aged,
pubmed-meshheading:15159311-Base Sequence,
pubmed-meshheading:15159311-Case-Control Studies,
pubmed-meshheading:15159311-Cohort Studies,
pubmed-meshheading:15159311-Confidence Intervals,
pubmed-meshheading:15159311-Female,
pubmed-meshheading:15159311-Ferredoxin-NADP Reductase,
pubmed-meshheading:15159311-Genetic Predisposition to Disease,
pubmed-meshheading:15159311-Genotype,
pubmed-meshheading:15159311-Humans,
pubmed-meshheading:15159311-Incidence,
pubmed-meshheading:15159311-Lymphoma, Non-Hodgkin,
pubmed-meshheading:15159311-Male,
pubmed-meshheading:15159311-Middle Aged,
pubmed-meshheading:15159311-Molecular Sequence Data,
pubmed-meshheading:15159311-Odds Ratio,
pubmed-meshheading:15159311-Polymerase Chain Reaction,
pubmed-meshheading:15159311-Polymorphism, Genetic,
pubmed-meshheading:15159311-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:15159311-Probability,
pubmed-meshheading:15159311-Prognosis,
pubmed-meshheading:15159311-Risk Assessment,
pubmed-meshheading:15159311-Sex Distribution
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults.
|
| pubmed:affiliation |
Department of Biomedical Sciences and Advanced Therapies, Center Study for Hemostasis and Thrombosis, University of Ferrara, C.so Giovecca 203, I-44100 Ferrara, Italy. d.gemmati@unife.it
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|