rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
2004-5-25
|
pubmed:abstractText |
The coding region determinant-binding protein (CRD-BP) is an RNA binding protein that recognizes c-myc and IGF-II leader 3 mRNAs as well as the oncofetal H19 RNA. CRD-BP exhibits an oncofetal pattern of expression and has been detected in the majority of colon (81%), breast (58.5%) and sarcoma (73%) tumors. The study of CRD-BP expression was extended in brain tumors and Non small cell lung (NSCL) carcinomas and 12/24 malignant, 2/5 benign neuroepithelial tumors and 4/15 of NSCL carcinomas were found positive. All normal matching tissues tested were found negative. The highest frequency (60%) of CRD-BP positive tumors was observed in meningiomas, either benign (11/18) or atypical (3/3). These findings confirm that CRD-BP expression is restricted in tumors; the frequency of its de novo expression may vary according to tumor type and appears to be an early event in the transformation process.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0304-3835
|
pubmed:author |
pubmed-author:CourtisNellyN,
pubmed-author:DimitriadisEuthimiosE,
pubmed-author:GiannopoulosAndreasA,
pubmed-author:IliadisKosmasK,
pubmed-author:IoannidisPanayotisP,
pubmed-author:KottaridiChristineC,
pubmed-author:MahairaLouizaL,
pubmed-author:NasioulasGeorgeG,
pubmed-author:PapaioannouDimitriosD,
pubmed-author:TalieriMaroulioM,
pubmed-author:TrangasTheoniT
|
pubmed:copyrightInfo |
Copyright 2004 Elsevier Ltd.
|
pubmed:issnType |
Print
|
pubmed:day |
25
|
pubmed:volume |
209
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
245-50
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:15159028-Adenocarcinoma,
pubmed-meshheading:15159028-Brain,
pubmed-meshheading:15159028-Brain Neoplasms,
pubmed-meshheading:15159028-Carcinoma, Large Cell,
pubmed-meshheading:15159028-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:15159028-Carcinoma, Squamous Cell,
pubmed-meshheading:15159028-Case-Control Studies,
pubmed-meshheading:15159028-Humans,
pubmed-meshheading:15159028-Lung,
pubmed-meshheading:15159028-Lung Neoplasms,
pubmed-meshheading:15159028-Meningeal Neoplasms,
pubmed-meshheading:15159028-Meningioma,
pubmed-meshheading:15159028-RNA-Binding Proteins,
pubmed-meshheading:15159028-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15159028-Tumor Markers, Biological
|
pubmed:year |
2004
|
pubmed:articleTitle |
Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors.
|
pubmed:affiliation |
Department of Genetics, St Savas Hospital, Athens, Greece.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|