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pubmed:abstractText |
The role of nitric oxide (NO) in apoptotic cell death has been extensively studied in recent years. However, reported results are inconsistent and often controversial, and the mechanisms underlying its diverse effects in apoptosis regulation remain unidentified. The present study attempted to determine whether in vivo administration of L-arginine, the substrate for NOS, at different time points during the course of myocardial ischemia and reperfusion may differentially regulate post-ischemic myocardial apoptosis, and if so, to investigate the mechanisms involved.
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pubmed:affiliation |
Department of Emergency Medicine, Thomas Jefferson University, 1020 Sansom Street, Thompson Building, Room 239, Philadelphia, PA 19107, USA.
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