15158143

Source:http://linkedlifedata.com/resource/pubmed/id/15158143

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0031621, umls-concept:C0225828, umls-concept:C0251991, umls-concept:C0439834, umls-concept:C0439851, umls-concept:C0521116, umls-concept:C1552596, umls-concept:C1947931, umls-concept:C1999216, umls-concept:C2349975
pubmed:issue	3
pubmed:dateCreated	2004-5-25
pubmed:abstractText	Phosphoinositide 3-kinase (PI3K) is a key component in regulating myocardial growth, survival and contractility. LY294002 and wortmannin are two PI3K inhibitors used widely to establish the role of PI3K. The goal of this study was to examine the effects of acute application of LY294002 and wortmannin on cardiac myocyte contractility and underlying mechanisms.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0077427
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz..., http://linkedlifedata.com/resource/pubmed/chemical/Androstadienes, http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Chromones, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Morpholines, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated, http://linkedlifedata.com/resource/pubmed/chemical/indo-1, http://linkedlifedata.com/resource/pubmed/chemical/wortmannin
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0008-6363
pubmed:author	pubmed-author:BackxPeter HPH, pubmed-author:CostantiniDannyD, pubmed-author:OuditGavin YGY, pubmed-author:RamirezRafael JRJ, pubmed-author:SunHuiH
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	62
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	509-20
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:15158143-Action Potentials, pubmed-meshheading:15158143-Androstadienes, pubmed-meshheading:15158143-Animals, pubmed-meshheading:15158143-Calcium, pubmed-meshheading:15158143-Cell Size, pubmed-meshheading:15158143-Chromones, pubmed-meshheading:15158143-Dose-Response Relationship, Drug, pubmed-meshheading:15158143-Indoles, pubmed-meshheading:15158143-Male, pubmed-meshheading:15158143-Mice, pubmed-meshheading:15158143-Mice, Inbred C57BL, pubmed-meshheading:15158143-Microscopy, Fluorescence, pubmed-meshheading:15158143-Morpholines, pubmed-meshheading:15158143-Myocytes, Cardiac, pubmed-meshheading:15158143-Patch-Clamp Techniques, pubmed-meshheading:15158143-Phosphatidylinositol 3-Kinases, pubmed-meshheading:15158143-Potassium Channels, Voltage-Gated, pubmed-meshheading:15158143-Sarcoplasmic Reticulum
pubmed:year	2004
pubmed:articleTitle	The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents.
pubmed:affiliation	Department of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre and Division of Cardiology, University Health Network, University of Toronto Fitzgerald Building, 150 College St., Toronto, Ontario, Canada M5S 3E2.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't