Source:http://linkedlifedata.com/resource/pubmed/id/15158093
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2004-5-25
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| pubmed:abstractText |
A multi-centre, population-based case-control study of lymphoma among adults was conducted in Germany from 1999-2003. The study comprised 700 incident cases (Hodgkin lymphomas and non Hodgkin's lymphoma, NHL) in the age range 18-80 years and 700 age-, sex- and area-matched controls obtained from population registries. Diagnosis was based on the REAL/WHO classification. Information on demographic characteristics, lifestyle, medical history and occupation was obtained by in-person interviews. Each participant was asked for a 24 ml blood sample. First results are focused on basic demographic characteristics, contact to animals, childhood diseases and vaccinations. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. The ORs for lymphoma were decreased for exposure to sheep and goats (OR = 0.7; 95% CI = 0.5-0.9), for rabbits and hare (OR = 0.7; 95% CI = 0.5-0.9), measles infection (OR = 0.6; 95% CI = 0.5-0.9), Bordetella pertussis infection (OR = 0.7; 95% CI = 0.6-0.95), and tetanus vaccination (OR = 0.5; 95% CI = 0.3-0.9). Increased risk of lymphoma was associated with exposure to cattle (OR = 1.3; 95% CI = 1.03-1.7) and immunization for tuberculosis (OR = 1.5; 95% CI = 0.997-2.4). The results of this study are partly consistent with the hygiene hypothesis. The inconsistencies of some of the findings with an explanation by the Th1/Th2 paradigm, however, warrant further research and may indicate that broader explanatory concepts are needed.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
0145-2126
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
713-24
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15158093-Adolescent,
pubmed-meshheading:15158093-Adult,
pubmed-meshheading:15158093-Aged,
pubmed-meshheading:15158093-Aged, 80 and over,
pubmed-meshheading:15158093-Animals,
pubmed-meshheading:15158093-Case-Control Studies,
pubmed-meshheading:15158093-Environmental Exposure,
pubmed-meshheading:15158093-Female,
pubmed-meshheading:15158093-Germany,
pubmed-meshheading:15158093-Humans,
pubmed-meshheading:15158093-Hypersensitivity,
pubmed-meshheading:15158093-Infection,
pubmed-meshheading:15158093-Logistic Models,
pubmed-meshheading:15158093-Lymphoma,
pubmed-meshheading:15158093-Male,
pubmed-meshheading:15158093-Middle Aged,
pubmed-meshheading:15158093-Risk Factors,
pubmed-meshheading:15158093-T-Lymphocyte Subsets,
pubmed-meshheading:15158093-Vaccination
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Population-based study of lymphoma in Germany: rationale, study design and first results.
|
| pubmed:affiliation |
Deutsches Krebsforschungszentrum, Abteilung Klinische Epidemiologie, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. n.becker@dkfz-heidelberg.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|