Linked Life Data

15157507

Source:http://linkedlifedata.com/resource/pubmed/id/15157507

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2004-5-25
pubmed:abstractText
The first events in the lives of proteins are the most hazardous. Starting at the ribosome, nascent polypeptides undergo complex folding processes endangered by aggregation reactions. Proteins with organellar destinations require correct targeting to the translocation machineries and prevention from premature folding. The high precision and speed of these processes is ensured by a cystosolic system consisting of molecular chaperones, folding catalysts and targeting factors. This review focuses on the interactions of this system with nascent polypeptides and discusses new concepts for protein folding in the cytosol. It is proposed that folding and targeting are promoted by a flexible network of multiple unassisted and assisted pathways.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Dec
pubmed:issn
0962-8924
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
480-6
pubmed:year
1996
pubmed:articleTitle
Growing up in a dangerous environment: a network of multiple targeting and folding pathways for nascent polypeptides in the cytosol.
pubmed:affiliation
Zentrum für Molekulare Biologie, Universität Heidelberg, Germany. bukau@sun0.urz.uni-heidelberg.de
pubmed:publicationType
Journal Article